졸피뎀
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졸피뎀 속성
- 녹는점
- 189-191°C
- 밀도
- 1.12±0.1 g/cm3(Predicted)
- 인화점
- 9℃
- 저장 조건
- Store at RT
- 용해도
- 45%(w/v) 수성 2-히드록시프로필-β-시클로덱스트린: 0.3mg/mL
- 산도 계수 (pKa)
- 6.2(at 25℃)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- 수용성
- <10mg/L(상온)
- CAS 데이터베이스
- 82626-48-0(CAS DataBase Reference)
- NIST
- Zolpidem(82626-48-0)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
유엔번호(UN No.) | UN1230 - class 3 - PG 2 - Methanol, solution | ||
WGK 독일 | 3 | ||
RTECS 번호 | NJ5109750 | ||
HS 번호 | 2933996500 |
졸피뎀 C화학적 특성, 용도, 생산
개요
Zolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.화학적 성질
Off-White Solid용도
A selective benzodiazepine receptor agonist not related chemically to benzodiazepines정의
ChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.일반 설명
Zolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.졸피뎀 준비 용품 및 원자재
원자재
메틸아민
염화옥살릴
Acetamide, 2-diazo-N,N-dimethyl-
6-메틸-2-(4-메틸페닐)이미다조[1,2-a]피리딘
2-브로모-N,N-디메틸아세트아미드
2-프로피나미드,N,N-디메틸-
6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
Benzenebutanamide, β-bromo-N,N,4-trimethyl-γ-oxo-
디메틸아민
다이메틸아민 수화염화물
2-Amino-5-methylpyridine
준비 용품
졸피뎀 관련 검색:
N,N-디메틸아세트아미드 γ-피콜린 피리딘 1-메틸이미다졸 2,6-루티딘 아세트아마이드 졸피뎀
ZOLPIDEM TARTRATE - * PSY
Zopidem Tartrate Intermediates
Zolpidic Acid
ZOLPIDEM HEMITARTRATE,ZOLPIDEM TARTRATE,Zolpidem Tartrate Tablet,ZOLPIDEM TARTRATE EP C IV
2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE
6-METHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]-PYRIDINE-3-ACETIC ACID (FOR ZOLPIDEM)
Zolpidem-d6 6-Carboxylic Acid
2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE
Imidazo[1,2-a]pyrimidine
2-(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE
2-(6-METHYL-2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE