Oxalyl chloride
- CAS No.
- 79-37-8
- Chemical Name:
- Oxalyl chloride
- Synonyms
- OXALYL DICHLORIDE;Oxalyl;OC;formyl chloride;Oxalic dichloride;COX;ETHANEDIOYL DICHLORIDE;Oxalic chloride;Oxaloyl chloride;Oxalyl chloride solution 2.0 M in methylene chloride
- CBNumber:
- CB7854408
- Molecular Formula:
- C2Cl2O2
- Molecular Weight:
- 126.93
- MOL File:
- 79-37-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/19 16:21:48
| Melting point | -10--8 °C (lit.) |
|---|---|
| Boiling point | 62-65 °C (lit.) |
| Density | 1.5 g/mL at 20 °C (lit.) |
| vapor density | 4.4 (vs air) |
| vapor pressure | 150 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 176-178°C |
| storage temp. | Store Cold |
| solubility | Chloroform (Soluble), Ethyl Acetate |
| form | Liquid |
| color | APHA: 0-150 |
| Odor | penetrating odor |
| Water Solubility | reacts |
| Decomposition | 176-178 ºC |
| Sensitive | Moisture Sensitive |
| Merck | 14,6914 |
| BRN | 1361988 |
| Dielectric constant | 3.5（21℃） |
| Exposure limits |
ACGIH: TWA 50 ppm OSHA: TWA 25 ppm; STEL 125 ppm NIOSH: IDLH 2300 ppm |
| Stability | Stable. Incompatible with bases, alcohols, steel, oxidizing agents, alkali metals. Moisture sensitive. Reacts violently with water, liberating toxic gas. |
| InChIKey | CTSLXHKWHWQRSH-UHFFFAOYSA-N |
| CAS DataBase Reference | 79-37-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Oxalyl chloride(79-37-8) |
| EPA Substance Registry System | Ethanedioyl dichloride (79-37-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H260-H301+H331-H314 | |||||||||
| Precautionary statements | P223-P231+P232-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 14-20-29-34-40-23/24/25-37-35-23 | |||||||||
| Safety Statements | 26-36/37/39-43-45-8-24/25-23-27 | |||||||||
| RIDADR | UN 2927 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | KI2950000 | |||||||||
| F | 9-19-21 | |||||||||
| Hazard Note | Toxic/Corrosive/Store Cold/Lacrymatory | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29171990 | |||||||||
| NFPA 704 |
|
Oxalyl chloride price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | O8801 | Oxalyl chloride reagent grade, 98% | 79-37-8 | 25G | ₹2749.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O8801 | Oxalyl chloride reagent grade, 98% | 79-37-8 | 100G | ₹5434.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | O8801 | Oxalyl chloride reagent grade, 98% | 79-37-8 | 1KG | ₹25980 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.07066 | Oxalyl chloride for synthesis | 79-37-8 | 25ML | ₹4240 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.07066 | Oxalyl chloride for synthesis | 79-37-8 | 100ML | ₹7110 | 2022-06-14 | Buy |
Oxalyl chloride Chemical Properties,Uses,Production
Chemical Properties
colourless liquid with a pungent odour
Uses
Oxalyl Chloride is used in the preparation of cardiolipin analogs which induce peroxidase activity by Cytochrome C. It is also used in the preparation of fluorescent indicators for cytosolic calcium.
Application
Oxalyl chloride is used in organic synthesis. It may be used in the following processes:
Unncatalyzed reaction of silyl ketene acetals with oxalyl chloride yeilds symmetrical pulvinic acids.
Catalytic syntheses of N-heterocyclic ynones and ynediones by in situ activation of carboxylic acids with oxalyl chloride.
Oxalyl chloride was reportedly used in the first synthesis of dioxane tetraketone.
Preparation of Mosher′s acid chloride by reacting with Mosher′s acid in the presence of DMF.
Activation of dimethyl sulfoxide for use in the oxidation of long-chain alcohols to carbonyls.
Activation of α-keto carboxylic acids and N-heterocyclic carboxylic acids for alkynylation to form ynediones and N-heterocyclic ynones, respectively.
Production Methods
Oxalyl Chloride is produced by the reaction of anhydrous oxalic acid and phosphorus pentachloride.
Reactions
Oxalyl Chloride vigorously reacts with water, alcohols, and amines, and is employed for the synthesis of agrochemicals, pharmaceuticals, and fine chemicals.
General Description
Oxalyl chloride is a commonly used chlorinating reagent that can be prepared by the reaction of oxalic acid and phosphorus pentachloride.
Safety Profile
Poison. Violently decomposed by water and alcohol. Severe irritant to skin, eyes, respiratory tract. Explodeson contact with dimethyl sulfoxide. Forms shock-sensitive explosive mixtures with potassium or with K-Na alloy. Will react with water or steam to
Oxalyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-Thiazolemethanamine, 2-amino-N,N-dimethyl-
BENZOYL ISOCYANATE
o-Anisoyl chloride
1,3-BENZOTHIAZOLE-2-CARBONYL CHLORIDE
Faropenem sodium hemipentahydrate
4-(chloromethyl)-2-thiazolamine
2,6-DICHLORO-4-ISOCYANATOPYRIDINE
2-(5-BENZYLOXY-1H-INDOL-3-YL)-ETHANOL
2,6-Dichloropyridine-4-carboxaldehyde
4-Propylbenzoic acid
Etodolac
2-(5-BENZYLOXY-1H-INDOL-3-YL)-ETHYLAMINE
2-[5-(Benzyloxy)-1H-indol-3-yl]-2-oxoacetic acid ,97%
4-Biphenylcarbonyl chloride
5-BENZYLOXYINDOLE-3-GLYOXYLAMIDE
4-Bromo-1-chloroisoquinoline
4-HO-DET
1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid
Alpidem
4-Cyanobenzoyl chloride
2-(2-NITROPHENYL)ACRYLALDEHYDE
2-Chlorobenzoyl isocyanate
2,6-Difluorobenzoyl isocyanate
1,5-Diazabicyclo[4.3.0]non-5-ene
Zolpidem
5-BROMOSALICYLAMIDE
4-DIMETHYLAMINOBENZOYL CHLORIDE
CHLOROACETYL ISOCYANATE
4-AMINOBENZANILIDE
3-DIMETHYLAMINOBENZOYL CHLORIDE HYDROCHLORIDE
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Global( 518)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| ANJI BIOSCIENCES | +91-9000100077 +91-9000100077 | Hyderabad, India | 430 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Anshul Specialty Molecules Pvt. Ltd | +91-2226865566 +91-2226865566 | Mumbai, India | 23 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Chloritech Industries | +91-9227140314 +91-9227622171 | Gujarat, India | 11 | 58 | Inquiry |
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| DeliCare LifeSciences Pvt Ltd | +91-7977363866 +91-7977363866 | Maharashtra, India | 25 | 58 | Inquiry |
| Omshri Labs Pvt Ltd | +91-7977270534 +91-9833689647 | Maharashtra, India | 46 | 58 | Inquiry |
| Spectrochem Pvt., Ltd. | 91-22-22016968 | Maharashtra, India | 183 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| ANJI BIOSCIENCES | 58 |
| JSK Chemicals | 58 |
| Anshul Specialty Molecules Pvt. Ltd | 58 |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | 58 |
| Chloritech Industries | 58 |
| Otto Chemie Pvt Ltd | 58 |
| DeliCare LifeSciences Pvt Ltd | 58 |
| Omshri Labs Pvt Ltd | 58 |
| Spectrochem Pvt., Ltd. | 58 |
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79-37-8
ClOCCOCl
ClCOCOCl
HCOCl
C2O2Cl2
CHClO