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Faropenem sodium hemipentahydrate

Faropenem sodium hemipentahydrate Structure
CAS No.
106560-14-9
Chemical Name:
Faropenem sodium hemipentahydrate
Synonyms
FROPENEM;FAROPENEM;Faropenem Sodium Impurity G;Faropenem sodium hemi 5-hydrate;Faropenem sodium hemipentahydrate;Faropenem sodium hemipentahydrate USP/EP/BP;6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid;6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CBNumber:
CB1300660
Molecular Formula:
C12H15NO5S
Molecular Weight:
285.32
MOL File:
106560-14-9.mol
Modify Date:
2023/5/4 17:34:31
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Faropenem sodium hemipentahydrate Properties

Boiling point 570.2±50.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
pka 4.00±0.40(Predicted)
CAS DataBase Reference 106560-14-9

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Faropenem sodium hemipentahydrate Chemical Properties,Uses,Production

Description

Farom was launched in Japan for use as an antibiotic against common respiratory tract pathogens. It can be prepared by several related routes of about seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated azetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable. Farom is the most active β-lactam against anaerobes (more than cefaclor, cefixime and amoxicillin) but also has activity against Gram-positive, Gram-negative and enterobacteriaceae. It is equally active against strains carrying plasmid and chromosome mediated β-lactamases. The short plasma elimination half-life is the result of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis by extended spectrum β-lactamases than some second and third generation cephalosporins.

Uses

Treatmentof bacterial infections.

Antimicrobial activity

An orally active penem with a broad spectrum of antibacterial activity, including activity against selected anaerobic pathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens, Enterobacter spp. and some Providencia spp. It generally retains activity against many Gram-positive organisms, but has no useful activity against Ps. aeruginosa. It has reduced activity against E. faecium, methicillin-resistant Staph. aureus (MRSA) and some strains of coagulase-negative staphylococci. It is stable to hydrolysis by extended spectrum β-lactamases, but is hydrolyzed by carbapenemases. Esterified prodrugs with increased bioavailability have been studied in clinical trials but have not received regulatory approval.

Faropenem sodium hemipentahydrate Preparation Products And Raw materials

Raw materials

TRIPHENYLMETHYL MERCAPTAN Triethyl phosphate Silver nitrate N,N-Diisopropylethylamine Tetrabutylammonium periodate
Oxalyl chloride Chloromethane
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Preparation Products

Faropenem sodium hemipentahydrate Suppliers

Global( 136)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Kopran Ltd +91-9920289074 +91-9820220525 Maharashtra, India 21 58 Inquiry
Mascot Industries Pvt., Ltd. +91-9825849755 +91-9825849755 Ahmedabad, India 16 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29896 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-592-6051114 +8618959220845 China 6387 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd +8613580539051 CHINA 21149 58 Inquiry
Supplier Advantage
Kopran Ltd 58
Mascot Industries Pvt., Ltd. 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
career henan chemical co 58
Xiamen AmoyChem Co., Ltd 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58

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[5R-[3(R^<*>^)，5α，6α(R^<*>^)]]-6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azobicyclo[3.2.0]leapt-2- ene-2-carboxylicacid (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-keto-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid (+)-(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, [5R-[3(R*),5α,6α(R*)]]- 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, (5R,6S)- 6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt hemipentahydrate Faropenem sodium hemipentahydrate FAROPENEM FROPENEM (5R,6R)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid Faropenem sodium hemipentahydrate USP/EP/BP (5R,6S)-6-((R)-1-Hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Faropenem-d5Q: What is Faropenem-d5 Q: What is the CAS Number of Faropenem-d5 Q: What are the applications of Faropenem-d5 Faropenem sodium hemi 5-hydrate Faropenem Sodium Impurity G 106560-14-9 22547-49-3 2C12H14NNaO5S5H20 2C12H14NO5S2Na5H2O API