Furosemide

Furosemide Properties

Melting point	220 °C (dec.) (lit.)
Boiling point	582.1±60.0 °C(Predicted)
Density	1.606
refractive index	1.6580 (estimate)
Flash point	11 °C
storage temp.	2-8°C
solubility	Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
pka	pKa 3.8 (Uncertain)
form	powder
color	White to Off-White
Water Solubility	Soluble in acetone, DMF or methanol. Slightly soluble in water
Merck	14,4309
BCS Class	2 (CLogP), 4 (LogP)
Stability	Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents.
InChIKey	ZZUFCTLCJUWOSV-UHFFFAOYSA-N
CAS DataBase Reference	54-31-9(CAS DataBase Reference)
IARC	3 (Vol. 50) 1990
EPA Substance Registry System	Furosemide (54-31-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H360FD
Precautionary statements	P202-P264-P270-P280-P301+P312-P308+P313
Hazard Codes	T,F,Xi
Risk Statements	61-39/23/24/25-23/24/25-11-36/37/38
Safety Statements	7-16-36/37-45-53-36/37/39-22-36-26
RIDADR	UN 1230 3/PG 2
WGK Germany	3
RTECS	CB2625000
HS Code	2935904000
Hazardous Substances Data	54-31-9(Hazardous Substances Data)
Toxicity	LD50 orally in female, male rats: 2600, 2820 mg/kg (Goldenthal)

Furosemide price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	F4381	Furosemide	54-31-9	1G	₹5715.6	2022-06-14	Buy
Sigma-Aldrich(India)	SAB1306550	ANTI-TM173(C-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	54-31-9	400μL	₹47796.6	2022-06-14	Buy
Sigma-Aldrich(India)	F4381	Furosemide	54-31-9	5G	₹27019.2	2022-06-14	Buy
Sigma-Aldrich(India)	SAB1306152	ANTI-TM173(C-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	54-31-9	400μL	₹47796.6	2022-06-14	Buy
Sigma-Aldrich(India)	F4381	Furosemide	54-31-9	10G	₹31457.45	2022-06-14	Buy

Product number	Packaging	Price	Buy
F4381	1G	₹5715.6	Buy
SAB1306550	400μL	₹47796.6	Buy
F4381	5G	₹27019.2	Buy
SAB1306152	400μL	₹47796.6	Buy
F4381	10G	₹31457.45	Buy

Furosemide Chemical Properties,Uses,Production

Description

Furosemide (Item No. 26298) is an analytical reference standard categorized as a diuretic. Formulations containing diuretics, including furosemide, have been misused in sports for weight reduction and as masking agents in humans and to prevent exercise-induced pulmonary hemorrhage in racehorses. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .

Chemical Properties

white to light yellow crystal powde

Uses

Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic.

Definition

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration and anti-hypertensive agent.

General Description

Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless.

Air & Water Reactions

Light sensitive. Air sensitive. Slightly soluble in water.

Reactivity Profile

Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown to improve the stability of Furosemide. Incompatible with strong oxidizing agents .

Hazard

Poison; moderately toxic; teratogen; questionable carcinogen; mutagen.

Fire Hazard

Flash point data for Furosemide are not available; however, Furosemide is probably combustible.

Biological Activity

Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. Also acts as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-containing receptors than α 1-containing receptors.

Mechanism of action

Furosemide is a highly effective and quick-acting diuretic whose action, like all of the examined loop diuretics, is associated with blocking reabsorption of ions in the ascending bend of Henle’s loop. It is used for edema syndrome of various origins, edema of the lungs and brain, chronic renal insufficiency, some forms of hypertonic crises, and poisoning by barbiturates and other compounds excreted mainly with urine.

Clinical Use

Furosemide has a saluretic effect 8- to 10-fold that of the thiazide diuretics; however, it has a shorter duration of action (~6–8 hours). Furosemide causes a marked excretion of sodium, chloride, potassium, calcium, magnesium, and bicarbonate ions, with as much as 25% of the filtered load of sodium excreted in response to initial treatment. It is effective for the treatment of edemas connected with cardiac, hepatic, and renal sites. Because it lowers the blood pressure similar to the thiazide derivatives, one of its uses is in the treatment of hypertension.

Side effects

Clinical toxicity of furosemide and other loop diuretics primarily involves abnormalities of fluid and electrolyte balance. As with the thiazide diuretics, hypokalemia is an important adverse effect that can be prevented or treated with potassium supplements or coadministration of potassium-sparing diuretics. Increased calcium ion excretion can be a problem for postmenopausal osteopenic women, and furosemide generally should not be used in these individuals. Hyperuricemia, glucose intolerance, increased serum lipid levels, ototoxicity, and gastrointestinal side effects might be observed as well. Hypersensitivity reactions also are possible with furosemide (a sulfonamide-based drug), and cross-reactivity with other sulfonamide containing drugs is possible.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: change in the sensitivity of the ear to sound, tinnitus, unspecified effects on the heart, constriction of the arteries, a decrease in urine volume, interstitial nephritis, metabolic alkalosis, pulse rate decrease, fall in blood pressure. Ingestion can damage the liver. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and SOx.

Furosemide Preparation Products And Raw materials

Raw materials

Furfurylamine 2,4-Dichloro-5-sulfamoylbenzoic acid 2,4-Dichlorobenzoic acid 6-DichlorobenzoicAcid

Preparation Products

Triamterene

Furosemide Suppliers

Global( 656)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jigs Chemical ltd	+919099003427	Gujarat, India	239	58	Inquiry
HEMA PHARMACEUTICALS PVT LTD	+91-9537936912 +91-9537936912	Gujarat, India	48	58	Inquiry
THE MOLECULEZ	+91-7506703683 +91-7506703683	Maharashtra, India	79	58	Inquiry
Hem-Deep Organics Pvt. Ltd. (HOPL)	+91-9998689897 +91-9824114578	Gujarat, India	12	58	Inquiry
Ipca Laboratories Ltd	+91-2262105000 +91-2262105000	Maharashtra, India	61	58	Inquiry
Prachi Pharmaceuticals Pvt Ltd	+919004877711	Mumbai, India	36	58	Inquiry
Macleods Pharmaceuticals Limited	+91-2266762800 +91-2266762800	Maharashtra, India	116	58	Inquiry
Vasoya Industries Pvt Ltd	+91-9898083583 +91-9898083583	Gujarat, India	42	58	Inquiry
Lakshmi Farmachem	+91-9948795885 +91-9550886476	Telangana, India	407	58	Inquiry
Mangalam Drugs and Organics Ltd	+91-2222616300 +91-2222616200	Maharashtra, India	37	58	Inquiry

Supplier	Advantage
Jigs Chemical ltd	58
HEMA PHARMACEUTICALS PVT LTD	58
THE MOLECULEZ	58
Hem-Deep Organics Pvt. Ltd. (HOPL)	58
Ipca Laboratories Ltd	58
Prachi Pharmaceuticals Pvt Ltd	58
Macleods Pharmaceuticals Limited	58
Vasoya Industries Pvt Ltd	58
Lakshmi Farmachem	58
Mangalam Drugs and Organics Ltd	58

Furosemide Spectrum

Furosemide(54-31-9)MS Furosemide(54-31-9)¹HNMR Furosemide(54-31-9)¹³CNMR Furosemide(54-31-9)IR1 Furosemide(54-31-9)IR2 Furosemide(54-31-9)Raman

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5-(AMINOSULPHONYL)-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID 5-[AMINOSULFONYL]-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID LABOTEST-BB LT00244801 FUROSEMIDE 2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid FUROSEMIDE METHANOL SOLUTION FUROSEMIDE, RELATED COMPOUND B 4-CHLORO-5-SULFAMOYLANTHRANILIC ACID USP STANDARD FUROSEMIDE, EP STANDARD FUROSEMIDE, IMP. A (EP):2-CHLORO-4-FURFURYLAMINO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDARD) FUROSEMIDE, IMP. B (EP): 2,4-DICHLORO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDARD) FUROSEMIDE, MM(CRM STANDARD) FUROSEMIDE, WHO(CRM STANDARD) FUROSEMIDE, IMP. C (EP): 2-AMINO-4-CHLORO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDARD) FUROSEMIDE, IMPURITY A2-CHLORO-4-(FURFURYLAMINO)-5-SULPHAMOYLBENZOIC ACID EP STANDARD FUROSEMIDE, USP STANDARD FUROSEMIDE, BP STANDARD(CRM STANDARD) FUROSEMIDE, RELATED COMPOUND A 2-CHLORO-4-N-FURFURYLAMINO-5-SULFAMOYLBENZOIC ACID USP STANDARD FUROSEMIDE UNLABELED 1.0 MG/ML IN METHANOL Furosemide for peak identification ANTI-TM173(C-TERMINAL) antibody produced in rabbit ERIS TMEM173 Transmembrane protein 173 Furosemide (furosemide) Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-(2-furanylmethyl)amino- FUROSEMIDE,1.0MG/MLINMETHANOL FUROSEMIDE,USP 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid 4-CHLORO-N-(2-FURYLMETHYL)-5-SULPHAMOYLANTHRANILICACID FUROSEMIDE (FRUSEMIDE) 5-(Aminosulfonyl)-4-chloro-2-[(2-pyranylmethyl)-amino]benzonium acid 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid Furosemide solution Furix Furomex Lazax N-(2-furylmethyl)-4-chloro-5-sulfamylanthranilic acid "mita" 4-chloro-n-(2-furylmethyl)-5-sulfanoylanthranilicacid 4-chloro-n-furfuryl-5-sulfamoyl-anthranilicaci 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-benzoicaci 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-benzoicaci 5-(Aminosulfonyl)-4-chloro-2-[2-(furamyl-methyl)amino]-benzoicacid aluzine aquasin arasemide chlor-n-(2-furylmethyl)-5-sulfamylanthranilsaeure diurolasa endural franyl frusemin furanthril furanthryl furantril furose furosemide"mita" furosemidu furoside