Sulfisoxazole
- CAS No.
- 127-69-5
- Chemical Name:
- Sulfisoxazole
- Synonyms
- SULFAFURAZOLE;SIZ;SULFISOXAZOL;sulphisoxazole;Sosol;vagilia;Sulsoxin;Sulfalar;Gantrisin;SULFAFURAZOL
- CBNumber:
- CB1495500
- Molecular Formula:
- C11H13N3O3S
- Molecular Weight:
- 267.3
- MOL File:
- 127-69-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:01
| Melting point | 195°C |
|---|---|
| Boiling point | 482.2±55.0 °C(Predicted) |
| Density | 1.3486 (rough estimate) |
| refractive index | 1.6630 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | acetone: complete50 mg/ml |
| pka | 5.0(at 25℃) |
| form | Solid |
| color | White to Light Brown |
| Water Solubility | <0.1 g/100 mL at 22.5 ºC |
| λmax | 271nm(MeOH)(lit.) |
| Merck | 14,8952 |
| BRN | 6737262 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 127-69-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-(127-69-5) |
| IARC | 3 (Vol. 24, Sup 7) 1987 |
| EPA Substance Registry System | Sulfisoxazole (127-69-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WO9100000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29350030 | |||||||||
| Toxicity | LD50 orally in mice: 6800 mg/kg (Seki) | |||||||||
| NFPA 704 |
|
Sulfisoxazole price More Price(2)
Sulfisoxazole Chemical Properties,Uses,Production
Chemical Properties
white to cream powder
Uses
Sulfisoxazole is a sulfonamide based antibacterial that exhibits activity against wide spectrum of gram-negative and gram-positive bacterium.
Definition
ChEBI: A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.
Antimicrobial activity
Like all examined sulfanilamides, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci, and also colon bacillus. However, about 90% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids, which makes it the drug of choice for many systemic infections. Synonyms of this drug are gantrisin, fultrxin, sulfazin, sulfolar, and others.
General Description
Sulfisoxazole’s plasmahalf-life is 6 hours. This compound is a white, odorless,slightly bitter, crystalline powder. Its pKa is 5.0. At pH 6,this sulfonamide has a water solubility of 350 mg in100 mL, and its acetyl derivative has a solubility of 110 mgin 100 mL of water.Sulfisoxazole possesses the action and the uses of othersulfonamides and is used for infections involving sulfonamide-sensitive bacteria. It is claimed to be effective in thetreatment of Gram-negative urinary infections.
Air & Water Reactions
May be sensitive to prolonged exposure to air and light. Sensitive to heat. Slightly soluble in water.
Fire Hazard
Flash point data for Sulfisoxazole are not available; however, Sulfisoxazole is probably combustible.
Pharmaceutical Applications
3,4-Dimethyl-5-sulfanilamidoisoxazole. It is highly soluble,
even in acid urine. The spectrum and potency are typical of
the group. It is well absorbed, achieving a concentration of
around 20 mg/L 3–4 h after a 2 g oral dose.
Side effects are those common to other sulfonamides. It
is less prone than some other members of the group to cause
renal problems. Its principal use is in urinary tract infection,
and is present in some ophthalmic preparations.
Biological Activity
A selective ET A endothelin receptor antagonist (IC 50 values are 600 and 2200 nM for ET A and ET B receptors respectively).
Safety Profile
Mildly toxic by ingestion. An experimental teratogen. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Sulfisoxazole Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
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