Phthalylsulfathiazole
- CAS No.
- 85-73-4
- Chemical Name:
- Phthalylsulfathiazole
- Synonyms
- PST;ST8SIA4;Talidine;Thalinil;MGC34450;MGC61459;Anti-PST;Ftalazol;Taloudron;Thalazole
- CBNumber:
- CB2405964
- Molecular Formula:
- C17H13N3O5S2
- Molecular Weight:
- 403.43
- MOL File:
- 85-73-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/17 13:48:17
| Melting point | 198-204°C |
|---|---|
| Boiling point | 371.31℃[at 101 325 Pa] |
| Density | 1.4235 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.6390 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in ethanol (96 per cent). |
| form | Solid |
| pka | 3.40±0.36(Predicted) |
| color | White to Light Yellow |
| Water Solubility | 400mg/L at 28℃ |
| Merck | 14,7377 |
| BRN | 359901 |
| LogP | -2 at 28℃ |
| CAS DataBase Reference | 85-73-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Phthalylsulfathiazole(85-73-4) |
| EPA Substance Registry System | Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]- (85-73-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H412 | |||||||||
| Precautionary statements | P273-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | 3249 | |||||||||
| RTECS | TH8575000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 i.p. in mice: 920 mg/kg (Mattis) | |||||||||
| NFPA 704 |
|
Phthalylsulfathiazole price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | WH0006817M1 | Monoclonal Anti-SULT1A1 antibody produced in mouse clone 1F8, ascites fluid | 85-73-4 | 200μL | ₹48018.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | HPA053995 | Anti-ST8SIA4 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody | 85-73-4 | 100μL | ₹41436.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | HPA051126 | Anti-ST8SIA4 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 85-73-4 | 100μL | ₹41436.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | HPA049500 | Anti-SULT1A1 antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution | 85-73-4 | 100μL | ₹41436.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | AV49134 | Anti-SULT1A1 antibody produced in rabbit affinity isolated antibody | 85-73-4 | 100μL | ₹48873.3 | 2022-06-14 | Buy |
Phthalylsulfathiazole Chemical Properties,Uses,Production
Chemical Properties
White or yellowish-white, crystalline powder.
Uses
Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.
Definition
ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.
Preparation
It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.
It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.
World Health Organization (WHO)
Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.
Phthalylsulfathiazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Green Cross Export Private Limited | 91-79-29795951 | Gujarat, India | 56 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| DM Pharma | 91-44-28172391 | Tamil Nadu, India | 110 | 58 | Inquiry |
| Global Chem Asia Pacific | 91-9849161572 | Hyderabad, India | 255 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
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