Sulfathiazole sodium
- CAS No.
- 144-74-1
- Chemical Name:
- Sulfathiazole sodium
- Synonyms
- SODIUM SULFATHIAZOLE;SULFATHIAZOLE SODIUM SALT;ST-NA;Sulfathiazole(ST);Sulfathiazole Bp98;sodiumnorsulfazole;SULFATHIAZOLESOUDIM;solublesulfathiazole;sodiumsulphathiazole;SULFATHIAZOLE SODIUM
- CBNumber:
- CB6170572
- Molecular Formula:
- C9H10N3NaO2S2
- Molecular Weight:
- 279.31
- MOL File:
- 144-74-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/27 13:09:27
| storage temp. | Store at -20°C |
|---|---|
| solubility | H2O: soluble50mg/mL |
| form | powder |
| color | white to off-white |
| BRN | 3802297 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C9H9N3O2S2.Na.H/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;;/h1-6H,10H2,(H,11,12);; |
| InChIKey | PLYRQFRFHFKJLU-UHFFFAOYSA-N |
| SMILES | S(C1C=CC(N)=CC=1)(=O)(=O)NC1SC=CN=1.[NaH] |
| CAS DataBase Reference | 144-74-1(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-2-thiazolyl-, monosodium salt (144-74-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-23 |
| WGK Germany | 2 |
| RTECS | WP2450000 |
| F | 10 |
Sulfathiazole sodium Chemical Properties,Uses,Production
Description
Sulfathiazole sodium salt is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal′s only source of available folate is from their diet. Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Uses
Sulfathiazole sodium salt is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA). It can also be used in biological study of thermotherapy and sulfonamide antibiotics deciphered Cyanobacteria and Proteobacteria microbiome in huanglongbing-affected Citrus paradise and Citrus limon.
General Description
Chemical structure: sulfonamide
Biochem/physiol Actions
Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Sulfathiazole sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12585 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | China | 5873 | 58 | Inquiry |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | China | 5987 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | China | 1143 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18623 | 58 | Inquiry |