Sulfathiazole
- CAS No.
- 72-14-0
- Chemical Name:
- Sulfathiazole
- Synonyms
- ST;NORSULFAZOLE;Sulphathiazole;Norsulfazol;SULFATHIAZOL;Sulfathiazloe;Duatok;Dulana;m&b760;m+b760
- CBNumber:
- CB6133470
- Molecular Formula:
- C9H9N3O2S2
- Molecular Weight:
- 255.32
- MOL File:
- 72-14-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/24 19:19:26
| Melting point | 200-202 °C (lit.) |
|---|---|
| Boiling point | 479.5±47.0 °C(Predicted) |
| Density | 1.4629 (rough estimate) |
| refractive index | 1.6560 (estimate) |
| storage temp. | 2-8°C |
| solubility | 0.5g/l |
| pka | 7.2(at 25℃) |
| form | Solid |
| color | White |
| Water Solubility | Insoluble (<0.1 g/100 mL at 21 ºC) |
| Merck | 14,8943 |
| BRN | 226178 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | JNMRHUJNCSQMMB-UHFFFAOYSA-N |
| CAS DataBase Reference | 72-14-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Sulfathiazole(72-14-0) |
| EPA Substance Registry System | Sulfathiazole (72-14-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H412 | |||||||||
| Precautionary statements | P261-P264-P271-P273-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WP2360000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29350090 | |||||||||
| NFPA 704 |
|
Sulfathiazole price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S9876 | Sulfathiazole | 72-14-0 | 100G | ₹5282.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9876 | Sulfathiazole | 72-14-0 | 250G | ₹21260.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.21112 | N1-2-Thiazolylsulfanilamid for synthesis | 72-14-0 | 5G | ₹3080.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.21112 | N1-2-Thiazolylsulfanilamid for synthesis | 72-14-0 | 250G | ₹11250.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46902 | Sulfathiazole VETRANAL?, analytical standard | 72-14-0 | 250MG | ₹4633.1 | 2022-06-14 | Buy |
Sulfathiazole Chemical Properties,Uses,Production
Chemical Properties
white to cream powder
Uses
Sulfonamide antibacterial.
Definition
ChEBI: A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.
World Health Organization (WHO)
Sulfathiazole, a sulfonamide anti-infective agent, was introduced more than 25 years ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Although preparations remain available, use of the drug has been discontinued in many countries.
General Description
White crystalline powder. Is dimorphous: form I is consists of prismatic rods and form II of six-sided plates and prisms. Insoluble in water and soluble in dil aqueous acid and aqueous base.
Air & Water Reactions
May be sensitive to heat, air and light during long-term storage . Insoluble in water.
Reactivity Profile
Sulfathiazole is an amino acid.
Fire Hazard
Flash point data for Sulfathiazole are not available, but Sulfathiazole is probably combustible.
Pharmaceutical Applications
2-Sulfanilamidothiazole. A short-acting compound (half-life
c. 4 h) with relatively high activity. Protein binding is c. 75%.
Its use has declined because of a high incidence of side effects.
It is one of the constituents of triple sulfonamide mixtures, of
which local preparations are still available.
Two compounds, phthalylsulfathiazole (sulfathalidine) and
succinylsulfathiazole (sulfasuxidine) owe their activity to the
slow liberation of sulfathiazole in the bowel. They are poorly
soluble and very little is absorbed after oral administration.
They were formerly used in the treatment of intestinal infections
and in bowel preparation before surgery. They are available
in multi-ingredient preparations in some countries.
Safety Profile
Human poison by unspecified route. Experimental poison by intraperitoneal route, Moderately toxic by intravenous, subcutaneous, and parenteral routes. Mildly toxic by ingestion. Human systemic effects by unspecified route: conjunctiva irritation, tubule changes, and allergic skin dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data, Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Sulfathiazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SYNOVA CHEMICALS | +91-9920741772 +91-9920741772 | Mumbai, India | 428 | 58 | Inquiry |
| Valens Molecules | +91-040-23417926 +91-4023417926 | Hyderabad, India | 10 | 58 | Inquiry |
| Ishita Drugs And Industries Ltd | +91-7226995614 +91-7226995613 | Telangana, India | 47 | 58 | Inquiry |
| Sachem | 91-9810014878 | Delhi, India | 75 | 58 | Inquiry |
| Global Chem Asia Pacific | 91-9849161572 | Hyderabad, India | 255 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SYNOVA CHEMICALS | 58 |
| Valens Molecules | 58 |
| Ishita Drugs And Industries Ltd | 58 |
| Sachem | 58 |
| Global Chem Asia Pacific | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |