AG 490
- ₹3800 - ₹43126.8
- Product name: AG 490
- CAS: 133550-30-8
- MF: C17H14N2O3
- MW: 294.3
- EINECS:
- MDL Number:MFCD00236452
- Synonyms:Zinc02557947;AG-490 (Tyrphostin B42);(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide AG-490(Tyrphostin B42);Tyrphostin AG 490 AG 490;AG 490, >=98%;(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide;AG490,AG-490;2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE
6 prices
Selected condition:
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 20MG
- 25MG
- 100MG
- 1G
- ManufacturerTCI Chemicals (India)
- Product numberT2962
- Product descriptionTyrphostin AG 490
- Packaging20MG
- Price₹3800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberT2962
- Product descriptionTyrphostin AG 490
- Packaging100MG
- Price₹8800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberT2962
- Product descriptionTyrphostin AG 490
- Packaging1G
- Price₹19500
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number658401
- Product descriptionAG 490 - CAS 133550-30-8 - Calbiochem A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC?? = 100 n
- Packaging5MG
- Price₹5880
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT3434
- Product descriptionTyrphostin AG 490 solid
- Packaging5MG
- Price₹10640.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT3434
- Product descriptionTyrphostin AG 490 solid
- Packaging25MG
- Price₹43126.8
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | T2962 | Tyrphostin AG 490 | 20MG | ₹3800 | 2022-05-26 | Buy |
TCI Chemicals (India) | T2962 | Tyrphostin AG 490 | 100MG | ₹8800 | 2022-05-26 | Buy |
TCI Chemicals (India) | T2962 | Tyrphostin AG 490 | 1G | ₹19500 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | 658401 | AG 490 - CAS 133550-30-8 - Calbiochem A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC?? = 100 n | 5MG | ₹5880 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T3434 | Tyrphostin AG 490 solid | 5MG | ₹10640.98 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T3434 | Tyrphostin AG 490 solid | 25MG | ₹43126.8 | 2022-06-14 | Buy |
Properties
Melting point :215°C(lit.)
Boiling point :615.2±55.0 °C(Predicted)
Density :1.337
storage temp. :-20°C
solubility :ethanol: 5 mg/mL
form :solid
pka :8.75±0.10(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
InChIKey :TUCIOBMMDDOEMM-ZSOIEALJSA-N
Boiling point :615.2±55.0 °C(Predicted)
Density :1.337
storage temp. :-20°C
solubility :ethanol: 5 mg/mL
form :solid
pka :8.75±0.10(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
InChIKey :TUCIOBMMDDOEMM-ZSOIEALJSA-N
Safety Information
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Signal word: | Danger | |||||||||||||||||||||
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Description
Tyrphostin AG 490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, Tyrphostin AG 490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, Tyrphostin AG 490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that Tyrphostin AG 490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by Tyrphostin AG 490 leads to lower levels of p85 phosphorylation and p-13 kinase activation.More related product prices
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