WORTMANNIN
- CAS No.
- 19545-26-7
- Chemical Name:
- WORTMANNIN
- Synonyms
- CS-731;KY 1242;sl-2052;KY 12420;WORTMANNIN;Wortmammin;Wortmannin,98%;WORTMANNINTOXIN;SL-2052;KY-12420;antibioticsl-2052
- CBNumber:
- CB7241293
- Molecular Formula:
- C23H24O8
- Molecular Weight:
- 428.43
- MOL File:
- 19545-26-7.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 234-240 °C |
|---|---|
| alpha | +80.0～+105.0゜(20℃/D)(c=0.1,C2H5OH) |
| Boiling point | 463.31°C (rough estimate) |
| Density | 1.2454 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| Flash point | 2℃ |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | powder |
| color | off-white |
| Sensitive | Light Sensitive |
| λmax | 296nm(lit.) |
| Merck | 14,10053 |
| BRN | 67676 |
| Stability | Stable for 1 year from date of purchase as supplied. Dried aliquots evaporated from ethanol may be stored at -20° for several months. Solutions however are not stable and must be used within one working day. Note |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 | |||||||||
| Hazard Codes | T+,T,Xi,Xn,F | |||||||||
| Risk Statements | 26/27/28-36/37/38-36-20/21/22-11 | |||||||||
| Safety Statements | 28-36/37-45-37/39-26-16 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB9641000 | |||||||||
| F | 3-8-10 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
WORTMANNIN price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W1628 | Wortmannin from Penicillium funiculosum, ≥98% (HPLC and TLC) | 19545-26-7 | 1MG | ₹11896.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W3144 | Wortmannin, Ready Made Solution from Penicillium funiculosum, ≥95% (HPLC) | 19545-26-7 | 250μL | ₹12236 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W1628 | Wortmannin from Penicillium funiculosum, ≥98% (HPLC and TLC) | 19545-26-7 | 5MG | ₹45670.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W1628 | Wortmannin from Penicillium funiculosum, ≥98% (HPLC and TLC) | 19545-26-7 | 10MG | ₹76424.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 681675 | Wortmannin - CAS 19545-26-7 - Calbiochem Wortmannin, CAS 19545-26-7, is a cell-permeable, potent, selective, and irreversible inhibitor of PI3-Kinase (IC?? = 5 nM). Does not affect any upstre | 19545-26-7 | 1MG | ₹13140 | 2022-06-14 | Buy |
WORTMANNIN Chemical Properties,Uses,Production
Chemical Properties
White to pale yellow powder
Uses
Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumour and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo.
Biological Activity
Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC 50 = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC 50 = 5.8 nM).
WORTMANNIN Preparation Products And Raw materials
Global( 210)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
19545-26-7(WORTMANNIN)Related Search:
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antibioticsl-2052
sl-2052
[1S-(1ALPHA,6BALPHA,9ABETA,11ALPHA,11BBETA)]-11-(ACETYLOXY)-1,6B,7,8,9A,10,11,11B-OCTAHYDRO-1-(METHOXYMETHYL)-9A,11B-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[4,5-H]-2-BENZOPYRAN-3,6,9-TRIONE
KY 1242
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione,11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-,(1S,6bR,9aS,11R,11bR)-
Wortmannin KY 1242
Wortmannin
(+)-Wortmannin
Wortmannin, Ready Made Solution
Wortmannin solution
Wortmannin, Penicillium funiculosum
(1S,6BR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b
(1S,6BR,9AS,11R,11BR) 11-(ACETYLOXY)-1,6B,7,8,9A,10,11,11B-OCTAHYDRO-1-(METHOXYMETHYL)-9A,11B-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[[4,5-H]-2-H]-2-BENZOPYRAN-3,6,9-TRIONE
WORTMANNIN FROM PENICILLIUM FUMICULOSUM
KY 12420
PI 3-KINASE INHIBITOR
WORTMANNIN, PENICILLIUM WORTMANNI
WORTMANNIN
Wortmannin,Penicilliumwortmannin
3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)- (9CI)
WORTMANNINTOXIN
WORTMANNIN, FROM PENICILLIUM FUNICULOSUM
(1S,6br,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
(1S)-1,6bβ,7,8,9a,10,11,11b-Octahydro-11β-acetyloxy-1-(methoxymethyl)-9aα,11bα-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
Wortmannin,98%
Wortmammin
WORTMANNIN FROM PENICILLIUM FUMICULASUM
Wortmannin,KY 12420
WORTMANNINWORTMANN
CS-731
SL-2052;KY-12420
Wortmannin - CAS 19545-26-7 - Calbiochem
Wortmannin, a multi-target inhibitor of PI3K and MLCK
WORTMANNIN USP/EP/BP
(1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
Wortmannin (SL-2052
Wortmannin from Talaromyces (Penicillium)
Wortmannin, 98%, a multi-target inhibitor of PI3K and MLCK
Wortmannin (99.5%)
Wortmannin (BR, 99%)
(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
19545-26-7
C23H24O8
Enzymes, Inhibitors, and Substrates
Enzyme Inhibitors by Type
Enzyme Inhibitors
Kinase/Phosphatase Biology
Serine/Threonine Kinase Inhibitors
Phosphatidylinositol 3-kinase (PI3K)
Other
Cell Signaling and Neuroscience
Cell Biology
Biochemicals and Reagents
BioChemical
Anti-cancer&immunity
inhibitor
Inhibitors
Signalling
Antibiotics