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AG 957

AG 957 Structure
CAS No.
140674-76-6
Chemical Name:
AG 957
Synonyms
AG 957;NSC 654705;TYRPHOSTIN 957;TYRPHOSTIN AG 957;LAVENDUSTIN C ANALOG;4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE;METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester;Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate;paxillin,NSC654705,c-Abl,Bcr-Abl,lipopolysaccharide,Tyrphostin AG-957,integrins,leukemia,tyrosine,Tyrphostin AG 957,hematopoiesis,AG-957,NSC-654705,AG 957,NSC 654705,AG957,Tyrphostin AG957,kinase,BCR/ABL,inhibit,cytoskeleton,Inhibitor,Chronic,myelogenous
CBNumber:
CB6100142
Molecular Formula:
C15H15NO4
Molecular Weight:
273.28
MOL File:
Mol file
Modify Date:
2024/7/2 8:55:12
Request For Quotation

AG 957 Properties

Boiling point 504.2±45.0 °C(Predicted)
Density 1.337±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: soluble
form crystalline solid
pka 10.30±0.43(Predicted)
color Off-white to light brown

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

AG 957 Chemical Properties,Uses,Production

Description

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 μM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC50 = 0.25 μM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl.

Uses

Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Also, it causes metabolic alterations in K562 cells. It is a COVID19-related research product.

AG 957 Preparation Products And Raw materials

Raw materials

Preparation Products

AG 957 Suppliers

Global( 44)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9268 58 Inquiry
InvivoChem 13549236410 China 6755 58 Inquiry
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 China 2997 58 Inquiry
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 China 5585 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
CHEMSWORTH 30
TargetMol Chemicals Inc. 58
InvivoChem 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
InvivoChem 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Cayman Chemical Company 81

AG 957 Spectrum

AG 957(140674-76-6)MSAG 957(140674-76-6)1HNMR

140674-76-6(AG 957)Related Search:

TYRPHOSTIN AG 879 TYRPHOSTIN AG 1296 TYRPHOSTIN B56 TYRPHOSTIN AG 1024 LAVENDUSTIN C
Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate NSC 654705 TYRPHOSTIN 957 TYRPHOSTIN AG 957 AG 957 4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE LAVENDUSTIN C ANALOG METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester paxillin,NSC654705,c-Abl,Bcr-Abl,lipopolysaccharide,Tyrphostin AG-957,integrins,leukemia,tyrosine,Tyrphostin AG 957,hematopoiesis,AG-957,NSC-654705,AG 957,NSC 654705,AG957,Tyrphostin AG957,kinase,BCR/ABL,inhibit,cytoskeleton,Inhibitor,Chronic,myelogenous 140674-76-6 Tyrosine Kinase (TK) Receptor Tyrosine Kinase Inhibitors Kinase/Phosphatase Biology Cell Biology Cell Signaling and Neuroscience BioChemical