AG 957
![AG 957 Structure](StructureFile/ChemBookStructure4/GIF/CB6100142.gif)
- CAS No.
- 140674-76-6
- Chemical Name:
- AG 957
- Synonyms
- AG 957;NSC 654705;TYRPHOSTIN 957;TYRPHOSTIN AG 957;LAVENDUSTIN C ANALOG;4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE;METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester;Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate;paxillin,NSC654705,c-Abl,Bcr-Abl,lipopolysaccharide,Tyrphostin AG-957,integrins,leukemia,tyrosine,Tyrphostin AG 957,hematopoiesis,AG-957,NSC-654705,AG 957,NSC 654705,AG957,Tyrphostin AG957,kinase,BCR/ABL,inhibit,cytoskeleton,Inhibitor,Chronic,myelogenous
- CBNumber:
- CB6100142
- Molecular Formula:
- C15H15NO4
- Molecular Weight:
- 273.28
- MOL File:
- Mol file
- Modify Date:
- 2024/7/2 8:55:12
AG 957 Chemical Properties,Uses,Production
Description
Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 μM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC50 = 0.25 μM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl.
Uses
Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Also, it causes metabolic alterations in K562 cells. It is a COVID19-related research product.
AG 957 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 957 Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
RD International Technology Co., Limited | 18024082417 | China | 9268 | 58 | Inquiry |
InvivoChem | 13549236410 | China | 6755 | 58 | Inquiry |
Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | China | 2997 | 58 | Inquiry |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | China | 5585 | 58 | Inquiry |
Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
Supplier | Advantage |
---|---|
CLEARSYNTH LABS LTD. | 58 |
CHEMSWORTH | 30 |
TargetMol Chemicals Inc. | 58 |
InvivoChem | 58 |
Aladdin Scientific | 58 |
RD International Technology Co., Limited | 58 |
InvivoChem | 58 |
Suzhou Zhixin Biotechnology Co., Ltd. | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 58 |
Cayman Chemical Company | 81 |