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TYRPHOSTIN B46

TYRPHOSTIN B46 Structure
CAS No.
133550-34-2
Chemical Name:
TYRPHOSTIN B46
Synonyms
AG 555;AG 555, >98%;TYRPHOSTIN B46;TYRPHOSTIN AG 555;TyrphostinB46 AG 555;TyrphostinB46 A 555;AG555（Tyrphostin B46）;AG 555, 10 mM in DMSO;TYRPHOSTIN AG 555, >98%;AG 555 (Tyrphostin AG 555)
CBNumber:
CB5469835
Molecular Formula:
C19H18N2O3
Molecular Weight:
322.36
MOL File:
133550-34-2.mol
Modify Date:
2025/4/17 18:22:24
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TYRPHOSTIN B46 Properties

Boiling point 621.1±55.0 °C(Predicted)
Density 1.273±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO or ethanol: soluble
form Powder
pka 8.82±0.10(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3

TYRPHOSTIN B46 Chemical Properties,Uses,Production

Description

AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC50 = 0.7 μM). It selectively inhibits EFGR over ErbB2 (IC50 = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM. It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC50 = 210 μM).

Uses

Inhibitor of EGF receptor kinase activity

Biological Activity

Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.7 μ M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G 1 growth arrest selectively in transformed cells (IC 50 values are 6.4 and 9.4 μ M in HPV16-immortalized and normal keratinocytes respectively).

TYRPHOSTIN B46 Preparation Products And Raw materials

Raw materials

Preparation Products

TYRPHOSTIN B46 Suppliers

Global( 94)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32239 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
TargetMol Chemicals Inc. United States 38648 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Guangzhou Weijia Technology Co., Ltd. 020-84224925 18300190102 CHINA 6748 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Guangzhou Weijia Technology Co., Ltd. 58

TYRPHOSTIN B46 Spectrum

TYRPHOSTIN B46(133550-34-2)1HNMR

133550-34-2(TYRPHOSTIN B46)Related Search:

TYRPHOSTIN A46 99%,TYRPHOSTIN A46 TYRPHOSTIN A46,AG 99 (Tyrphostin A46) TYRPHOSTIN B46 2-CYANO-3-(3,4-DIHYDROXY-5-IODO-PHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE CHEMBRDG-BB 9071188
TYRPHOSTIN AG 1024 TYRPHOSTIN RG 14620 TYRPHOSTIN B48 TYRPHOSTIN RG 13022
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N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE TYRPHOSTIN AG 555 TYRPHOSTIN B46 (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(3-PHENYLPROPYL)-2-PROPENAMIDE AG 555 ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE Tyrphostin B46, N-(3μ-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide AG 555 (Tyrphostin AG 555) 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-, (2E)- TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555 AG 555, >98% TYRPHOSTIN AG 555, >98% AG555（Tyrphostin B46） (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)acrylamide Tyrphostin AG-555,EGFR,Reverse Transcriptase,Bovine,Tyrphostin AG555,HER1,BPV,ErbB-1,Inhibitor,AG 555,Epidermal growth factor receptor,AG-555,AG555,inhibit,antiretroviral,Papillomavirus TyrphostinB46 AG 555 TyrphostinB46 A 555 AG 555 (Tyrphostin B46), EGFR-tyrosine kinase inhibitor AG 555, 10 mM in DMSO 133550-34-2 BioChemical Cell Biology Cell Signaling and Neuroscience Kinase/Phosphatase Biology Epidermal Growth Factor Receptor (EGFR) Receptor Tyrosine Kinase Inhibitors Protein Kinase Intracellular Signaling