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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >Cantharidin

Cantharidin

Cantharidin Structure
  • ₹3165.4 - ₹84077.78
  • Product name: Cantharidin
  • CAS: 56-25-7
  • MF: C10H12O4
  • MW: 196.2
  • EINECS:200-263-3
  • MDL Number:MFCD00134968
  • Synonyms:(1r,2s,3r,6s)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboxylic anhydride;CANTHARIDIN;dimethyl-3,6-epoxyperhydrophthalic anhydride;HEXAHYDRO-3A,7A-DIMETHYL-4,7-EPOXYISOBENZO-FURAN-1,3-DIONE;4,7-epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a-dimethyl-,(3a-alpha,4-beta ;4,7-epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a-dimethyl-,(3aalpha,4beta,7 ;4,7-epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a-dimethyl-,(3aalpha,4beta,7be ;7aalpha)-bet
6 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 25MG
  • 100MG
  • 500MG
  • 1ML
  • ManufacturerTCI Chemicals (India)
  • Product numberC0019
  • Product descriptionCantharidin min. 98.0 %
  • Packaging25MG
  • Price₹4100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC0019
  • Product descriptionCantharidin min. 98.0 %
  • Packaging100MG
  • Price₹12200
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1537
  • Product descriptionCantharidin Ready Made Solution 0.1?mg/mL in DMSO
  • Packaging1ML
  • Price₹3165.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7632
  • Product descriptionCantharidin
  • Packaging25MG
  • Price₹9417.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7632
  • Product descriptionCantharidin
  • Packaging100MG
  • Price₹25298.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7632
  • Product descriptionCantharidin
  • Packaging500MG
  • Price₹84077.78
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C0019 Cantharidin min. 98.0 % 25MG ₹4100 2022-05-26 Buy
TCI Chemicals (India) C0019 Cantharidin min. 98.0 % 100MG ₹12200 2022-05-26 Buy
Sigma-Aldrich(India) SML1537 Cantharidin Ready Made Solution 0.1?mg/mL in DMSO 1ML ₹3165.4 2022-06-14 Buy
Sigma-Aldrich(India) C7632 Cantharidin 25MG ₹9417.75 2022-06-14 Buy
Sigma-Aldrich(India) C7632 Cantharidin 100MG ₹25298.03 2022-06-14 Buy
Sigma-Aldrich(India) C7632 Cantharidin 500MG ₹84077.78 2022-06-14 Buy

Properties

Melting point :215-217 °C (lit.)
Boiling point :253.08°C (rough estimate)
Density :1.0357 (rough estimate)
refractive index :1.4699 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).
form :solution
color :white
Water Solubility :30mg/L(20 ºC)
Merck :14,1752
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 weeks.
InChIKey :DHZBEENLJMYSHQ-XCVPVQRUSA-N
LogP :-0.409 (est)
CAS DataBase Reference :56-25-7(CAS DataBase Reference)
IARC :3 (Vol. 10, Sup 7) 1987
NIST Chemistry Reference :Cantharidin(56-25-7)
EPA Substance Registry System :Cantharidin (56-25-7)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cantharidin is a natural toxicant of blister beetles. Cantharidin has been used as a medicinal agent for over 2000 years and is listed as a drug under the name of Mylabris in the medical monograph Materia Medica published in 77 AD. Some of the most ancient Chinese prescriptions (306–168 BC) refer to the use of Mylabris for the treatment of furuncles and piles.
Cantharidin can be used for topically (0.7%) treatment of warts, in which the skin under the wart blisters, thereby, lifting the wart off the skin. It is used to treat molluscum contagiosum. Cantharidin is a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A), which are potentially novel targets for anticancer therapies. Thus, cantharidin is exploited as anticancer drugs. Cantharidin is shown to be cytotoxic to cancer cells and stimulatory on the bone marrow. The renal toxicity of this drug has prevented its use in mainstream oncology.

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