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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Tyrosine derivatives >AG 490

AG 490

AG 490 Structure
  • ₹3800 - ₹43126.8
  • Product name: AG 490
  • CAS: 133550-30-8
  • MF: C17H14N2O3
  • MW: 294.3
  • EINECS:
  • MDL Number:MFCD00236452
  • Synonyms:Zinc02557947;AG-490 (Tyrphostin B42);(2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide AG-490(Tyrphostin B42);Tyrphostin AG 490 AG 490;AG 490, >=98%;(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide;AG490,AG-490;2-CYANO-3-[3,4-DIHYDROXYPHENYL]-N-[PHENYLMETHYL]-2-PROPENAMIDE
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 20MG
  • 25MG
  • 100MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberT2962
  • Product descriptionTyrphostin AG 490
  • Packaging20MG
  • Price₹3800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2962
  • Product descriptionTyrphostin AG 490
  • Packaging100MG
  • Price₹8800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2962
  • Product descriptionTyrphostin AG 490
  • Packaging1G
  • Price₹19500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number658401
  • Product descriptionAG 490 - CAS 133550-30-8 - Calbiochem A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC?? = 100 n
  • Packaging5MG
  • Price₹5880
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT3434
  • Product descriptionTyrphostin AG 490 solid
  • Packaging5MG
  • Price₹10640.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT3434
  • Product descriptionTyrphostin AG 490 solid
  • Packaging25MG
  • Price₹43126.8
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T2962 Tyrphostin AG 490 20MG ₹3800 2022-05-26 Buy
TCI Chemicals (India) T2962 Tyrphostin AG 490 100MG ₹8800 2022-05-26 Buy
TCI Chemicals (India) T2962 Tyrphostin AG 490 1G ₹19500 2022-05-26 Buy
Sigma-Aldrich(India) 658401 AG 490 - CAS 133550-30-8 - Calbiochem A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC?? = 100 n 5MG ₹5880 2022-06-14 Buy
Sigma-Aldrich(India) T3434 Tyrphostin AG 490 solid 5MG ₹10640.98 2022-06-14 Buy
Sigma-Aldrich(India) T3434 Tyrphostin AG 490 solid 25MG ₹43126.8 2022-06-14 Buy

Properties

Melting point :215°C(lit.)
Boiling point :615.2±55.0 °C(Predicted)
Density :1.337
storage temp. :-20°C
solubility :ethanol: 5 mg/mL
form :solid
pka :8.75±0.10(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
InChIKey :TUCIOBMMDDOEMM-ZSOIEALJSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Tyrphostin AG 490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, Tyrphostin AG 490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, Tyrphostin AG 490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that Tyrphostin AG 490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by Tyrphostin AG 490 leads to lower levels of p85 phosphorylation and p-13 kinase activation.

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Suppliers and manufacturers

Hebei Mojin Biotechnology Co., Ltd
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₹0.00 /25KG
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career henan chemical co
AG 490
₹2.00 /1kg
AG 490 CAS:133550-30-8
A.J Chemicals TCI Chemicals (India) Pvt. Ltd.
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
TargetMol Chemicals Inc.