Bosutinib
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- ₹10800 - ₹12730.2
- Product name: Bosutinib
- CAS: 380843-75-4
- MF: C26H29Cl2N5O3
- MW: 530.45
- EINECS:700-455-1
- MDL Number:MFCD07367846
- Synonyms:4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile;Bosutinib ( SKI-606 );Bosutinib for research;3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-Methoxyphenyl)aMino]-6-Methoxy-7-[3-(4-Methyl-1-piperazinyl)propoxy]-;Bosutinib(TINIBS );WAY-173606;Bosulif(bosutinib);4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile Bosutinib (SKI-606)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
- ottokemi
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0192
- Product descriptionBosutinib ≥98% (HPLC)
- Packaging5MG
- Price₹12730.2
- Updated2022-06-14
- Buy
- Manufacturerottokemi
- Product number B 4125
- Product descriptionBosutinib, ≥98% (HPLC)
- Packaging5mg
- Price₹10800
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PZ0192 | Bosutinib ≥98% (HPLC) | 5MG | ₹12730.2 | 2022-06-14 | Buy |
| ottokemi | B 4125 | Bosutinib, ≥98% (HPLC) | 5mg | ₹10800 | 2022-05-26 | Buy |
Properties
Melting point :116-120 ºC
Boiling point :649.7±55.0 °C(Predicted)
Density :1.36
vapor pressure :0-0Pa at 20℃
storage temp. :room temp
solubility :DMSO: ≥15mg/mL
pka :7.63±0.10(Predicted)
form :powder
color :off-white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :PICKMQXYAMDEPF-UHFFFAOYSA-N
LogP :3.3-4.3 at pH9.5
Surface tension :72.4mN/m at 3.6mg/L and 20℃
CAS DataBase Reference :380843-75-4(CAS DataBase Reference)
Boiling point :649.7±55.0 °C(Predicted)
Density :1.36
vapor pressure :0-0Pa at 20℃
storage temp. :room temp
solubility :DMSO: ≥15mg/mL
pka :7.63±0.10(Predicted)
form :powder
color :off-white to light brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :PICKMQXYAMDEPF-UHFFFAOYSA-N
LogP :3.3-4.3 at pH9.5
Surface tension :72.4mN/m at 3.6mg/L and 20℃
CAS DataBase Reference :380843-75-4(CAS DataBase Reference)
Safety Information
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Description
The non-receptor tyrosine kinases c-Src and Abl have important roles in cell signaling and cancer. Bosutinib is best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively). Consistent with this action, bosutinib can be effective in regulating tumor growth and differentiation. Bosutinib is best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively). Consistent with this action, bosutinib can be effective in regulating tumor growth and differentiation. Bosutinib also inhibits, at nanomolar concentrations, other members of the Src family (e.g., Yes, Fgr, Lck, Fyn), as well as members of the TEC family, and certain other kinases. These actions extend the usefulness of this compound to cancers beyond those involving Src and Abl.More related product prices
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