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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Tinib Antineoplastic drugs >Tandutinib

Tandutinib

Tandutinib Structure
  • ₹5860.8 - ₹11821.5
  • Product name: Tandutinib
  • CAS: 387867-13-2
  • MF: C31H42N6O4
  • MW: 562.7
  • EINECS:
  • MDL Number:MFCD09954147
  • Synonyms:Tandutinib;1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-;4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide;Unii-E1io3icj9a;Tandutinib(CT 53518);Tandutinib (MLN518);CT53518; MLN518;Tandutinib(TINIBS)
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 25MG
  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2672
  • Product descriptionTandutinib hydrochloride ≥98% (HPLC)
  • Packaging25MG
  • Price₹5860.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2672
  • Product descriptionTandutinib hydrochloride ≥98% (HPLC)
  • Packaging100MG
  • Price₹11821.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2672 Tandutinib hydrochloride ≥98% (HPLC) 25MG ₹5860.8 2022-06-14 Buy
Sigma-Aldrich(India) SML2672 Tandutinib hydrochloride ≥98% (HPLC) 100MG ₹11821.5 2022-06-14 Buy

Properties

Melting point :177-178°C
Boiling point :769.5±60.0 °C(Predicted)
Density :1.213±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :13.39±0.70(Predicted)
form :Solid
color :White to Off-White
CAS DataBase Reference :387867-13-2(CAS DataBase Reference)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 μM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.

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Suppliers and manufacturers

Sinoway Industrial co., ltd.
Tandutinib
₹0.00 /25kg
Tandutinib CAS:387867-13-2
career henan chemical co
Tandutinib
₹1.00 /1KG
Tandutinib CAS:387867-13-2
Manus Aktteva A.J Chemicals CLEARSYNTH LABS LTD.
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Xiamen AmoyChem Co., Ltd
CONIER CHEM AND PHARMA LIMITED
SIMAGCHEM CORP