Masitinib
- ₹0
- Product name: Masitinib
- CAS: 790299-79-5
- MF: C28H30N6OS
- MW: 498.64
- EINECS:226-164-5
- MDL Number:MFCD09954132
- Synonyms:MASITINIB;4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide;4-((4-Methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide;Ab 1010;Ab1010;Ab-1010;Mastinib;Masitinib(AB1010)
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Properties
Melting point :90-95°C
Density :1.280±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :13.24±0.70(Predicted)
color :Off-White to Pale Beige
Density :1.280±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :13.24±0.70(Predicted)
color :Off-White to Pale Beige
Safety Information
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Description
Masitinib is a tyrosine kinase, c-Kit, PDGFR, FGFR3, and FAK pathway inhibitor with IC50 of 150 ± 80, 200 ± 40 nM for KIT tyrosine phosphorylation and the recombinant wild-type KIT. Masitinib can enhance the antiproliferative effects of gemcitabine (GEM) in pancreatic cancer cells. Masitinib potently inhibits KIT with activating mutations in the juxtamembrane domain.More related product prices
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