CAL-101
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- Product name: CAL-101
- CAS: 870281-82-6
- MF: C22H18FN7O
- MW: 415.42
- EINECS:807-438-9
- MDL Number:MFCD19443647
- Synonyms:CAL101,CAL-101;CAL-101;GS1101;CAL-101 (GS-1101);5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone;CAL-101 (Idelalisib, GS-1101);(S)-2-(1-((9H-Purin-6-yl)aMino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one;4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylaMino)propyl]-
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Properties
Melting point :250-252oC
Boiling point :733.4±70.0 °C(Predicted)
Density :1.47
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :White solid.
pka :10.00±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Boiling point :733.4±70.0 °C(Predicted)
Density :1.47
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :White solid.
pka :10.00±0.10(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. CAL-101 is a cell permeable inhibitor of the PI3K catalytic subunit p110δ (IC50 = 2.5 nM) that demonstrates 40- to 300-fold selectivity against other PI3K class I enzymes (IC50s = 820, 565, and 89 nM for p110α, β, and γ, respectively). At 1 μM it can block constitutive PI3K signaling in malignant B-cell lines and primary patient tumor cells, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase, and apoptosis. It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.More related product prices
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