Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >BKM120 (NVP-BKM120, Buparlisib)

BKM120 (NVP-BKM120, Buparlisib)

BKM120 (NVP-BKM120, Buparlisib) Structure
  • ₹0
  • Product name: BKM120 (NVP-BKM120, Buparlisib)
  • CAS: 944396-07-0
  • MF: C18H21F3N6O2
  • MW: 410.39
  • EINECS:
  • MDL Number:MFCD18251596
  • Synonyms:5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine;5-(2,6-diMorpholinopyriMidin-4-yl)-4-(trifluoroMethyl)pyridin-2-aMine;BKM120 (NVP-BKM120);NVP-BKM-120;BKM120 (NVP-BKM120, Buparlisib);NVP-BKM120, Buparlisib;BKM120BASE;Buparlisib
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :143-147°C
Boiling point :645.7±65.0 °C(Predicted)
Density :1.382
storage temp. :-20°C
solubility :Soluble in DMSO (15 mg/ml)
form :White powder.
pka :5.94±0.50(Predicted)
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Phosphatidylinositol 3-kinases (PI3K) belong to a family of lipid kinases that is involved in many types of cancer. NVP-BKM120 is an orally bioavailable inhibitor of class I PI3K isoforms, potently blocking, in vitro, both p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM). It much less effectively inhibits the class III PI3K Vps34 and mammalian target of rapamycin and has no effect on PI4Kβ and several other kinases. NVP-BKM120 prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo. It can be particularly effective against certain types of cancer when combined with other modulators.

More related product prices

BEZ235 (NVP-BEZ235, Dactolisib) CAL-101 Pictilisib (GDC-0941) 1217486-61-7 MK-2206 2HCl Everolimus MK-4827 (tosylate) Nintedanib Ethanesulfonate Salt 1204669-58-8 Ruxolitinib phosphate BMS-794833 371942-69-7 356559-20-1 675576-98-4 R428

Related product price

Suppliers and manufacturers

career henan chemical co
BKM120 (NVP-BKM120, Buparlisib)
₹2.00 /1kg
BKM120 (NVP-BKM120, Buparlisib) CAS:944396-07-0
CLEARSYNTH LABS LTD. A.J Chemicals
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Zhengzhou Alfa Chemical Co.,Ltd
TargetMol Chemicals Inc.