Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Ethylpyridine > Alpelisib (BYL719)

Alpelisib (BYL719)

Alpelisib (BYL719) Structure
  • ₹0
  • Product name: Alpelisib (BYL719)
  • CAS: 1217486-61-7
  • MF: C19H22F3N5O2S
  • MW: 441.47
  • EINECS:
  • MDL Number:MFCD22417085
  • Synonyms:(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide;BYL-719 /BYL719;BLV-719;(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide;1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-;Alpelisib (BYL719);(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719;BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.391
storage temp. :Store at -20°C
solubility :≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :White solid.
pka :6.29±0.70(Predicted)
color :Off-white to light yellow
InChIKey :STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES :N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P314 Get medical advice/attention if you feel unwell.
P501 Dispose of contents/container to..…

Description

BYL719 is a selective inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). It is less effective against PI3K isoforms β, γ, and δ (IC50s = 1,156, 250, and 290 nM) as well as a range of related kinases. BYL719 is effective in vivo, as it dose-dependently inhibits the growth of PI3Kα-dependent xenograft tumors in mice. Effectiveness against wild type and mutant PI3Kα-dependent tumors may be augmented by combination therapy with inhibitors of other kinases. Combination therapy may be necessary, as loss of downstream pathway components can confer clinical resistance to BYL719.

More related product prices

BEZ235 (NVP-BEZ235, Dactolisib) 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- 871700-17-3 CAL-101 MK-2206 2HCl BKM120 (NVP-BKM120, Buparlisib) D-ERYTHRO-SPHINGOSINE Neratinib BI 2536 N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Fluoxetine hydrochloride 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid 918505-84-7 BML-275 Selumetinib KU-55933 Glucagon Receptor Antagonist I

Related product price

Suppliers and manufacturers

Wuhan Fortuna Chemical Co., Ltd
Alpelisib
₹0.00 /1G
Alpelisib CAS:1217486-61-7
Zibo Hangyu Biotechnology Development Co., Ltd
Alpelisib (BYL719)
₹50.00 /1kg
Alpelisib (BYL719) CAS:1217486-61-7
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Alpelisib
₹0.00 /1g
Alpelisib CAS:1217486-61-7
CLEARSYNTH LABS LTD. A.J Chemicals Pharmaffiliates Analytics and Synthetics P. Ltd Taj Mahal Vision Chemicals Private Limited SynZeal Research Pvt Ltd Pharma Affiliates
Hangzhou FandaChem Co.,Ltd.