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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Ethylpyridine > Alpelisib (BYL719)

Alpelisib (BYL719)

Alpelisib (BYL719) Structure
CAS No.
1217486-61-7
Chemical Name:
Alpelisib (BYL719)
Synonyms
Alpelisib;Piqray;BYL-719;CS-614;100803;BLV-719;BYL-719 /BYL719;Alpelisib (BYL719);BYL-719(Alpelisib);Alpelisib (BLY-719
CBNumber:
CB52604234
Molecular Formula:
C19H22F3N5O2S
Molecular Weight:
441.47
MOL File:
1217486-61-7.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
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Alpelisib (BYL719) Properties

Density 1.391
storage temp. Store at -20°C
solubility ≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form White solid.
pka 6.29±0.70(Predicted)
color Off-white to light yellow
InChIKey STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H373
Precautionary statements  P260-P314-P501
HS Code  29341000

Alpelisib (BYL719) Chemical Properties,Uses,Production

Description

BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.

brand name

Piqray

General Description

Class: lipid kinase; Treatment: breast cancer; Other name: NVP-BYL719; Elimination half-life = 13.7 h; Protein binding = 89%

Alpelisib (BYL719) Preparation Products And Raw materials

Raw materials

Acetamide,N-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]- 4-Methyl-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine 4-methyl-2-(2,2,2-trifluoro-1-methyl-1-trimethylsilanyloxy-ethyl)pyridine 1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-ol
1,1,1-trifluoro-2-(4-methylpyridin-2-yl)propan-2-yl methanesulfonate N-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)-1H-iMidazole-1-carboxaMide phenyl 4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-ylcarbamate L-Prolinamide 1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one
2-Acetyl-4-methylpyridine 2,4-Lutidine
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Preparation Products

Alpelisib (BYL719) Suppliers

Global( 219)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Taj Mahal Vision Chemicals Private Limited 07942557933 Mumbai, India 206 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Wuhan Fortuna Chemical Co., Ltd +86-027-59207850 China 5999 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 11027 58 Inquiry
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. +86-18600796368 +86-18600796368 China 49 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Taj Mahal Vision Chemicals Private Limited 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Wuhan Fortuna Chemical Co., Ltd 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 58
Hangzhou FandaChem Co.,Ltd. 55

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Alpelisib (BYL719) Spectrum

Alpelisib (BYL719)(1217486-61-7)1HNMR

1217486-61-7( Alpelisib (BYL719))Related Search:

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(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719 /BYL719 BLV-719 (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)- Alpelisib (BYL719) (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719 BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719(Alpelisib) (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid ALPELISIB;BYL-719; BYL 719 CS-614 Alpelisib - NVP-BYL719 | BYL-719 100803 (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide Alpelisib, 98%, a potent and selective PI3Kα inhibitor (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ISO 9001：2015 REACH Alpelisib (BLY-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidine BYL-719 Alpelisib Piqray Inhibitor,Phosphoinositide 3-kinase,PI3K,Alpelisib,inhibit,phosphorylation,p110α,cancer,BYL 719,antineoplastic,AKT,metastasis,mutant,BYL719,PIK3CA,breast Biopterin Impurity 2 (2S) - N1- [4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethylethyl) -4-pyridyl] -2-thiazolyl] -1,2-pyrrolidine dicarboxylamide 1217486-61-7 C19H22F3N5O2S Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR Api API