ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >DNA damage >ATM / ATR inhibitor >KU-55933
KU-55933
- CAS No.
- 587871-26-9
- Chemical Name:
- KU-55933
- Synonyms
- CS-63;U-55933;KV-55933;KU 55933 NEW;KU-55933, >99%;KU 55933, >=98%;KU55933; KU 55933;KU-55933 USP/EP/BP;ATM Kinase Inhibitor;KU-55933 (ATM Kinase Inhibitor)
- CBNumber:
- CB8503709
- Molecular Formula:
- C21H17NO3S2
- Molecular Weight:
- 395.49
- MOL File:
- 587871-26-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 628.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.419±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml) |
| pka | 0.33±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
KU-55933 price More Price(2)
KU-55933 Chemical Properties,Uses,Production
Uses
KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.
Biological Activity
Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.
Biochem/physiol Actions
KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
KU-55933 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 155)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | China | 10297 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
587871-26-9(KU-55933)Related Search:
2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE
2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
KU-55933 (ATM Kinase Inhibitor)
KU-55933, >99%
KV-55933
2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor)
KU 55933, >=98%
ATM Kinase Inhibitor
KU-55933 (ATM KINASE INHIBITOR);KU 55933; KU55933
U-55933
CS-63
KU55933; KU 55933
KU 55933 NEW
4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-
KU-55933 USP/EP/BP
ATM Kinase Inhibitor Ku-55933 Ku55933
KU55933,Inhibitor,inhibit,Ataxia telangiectasia mutated,KU-55933,KU 55933,ATM/ATR,ATM and RAD3 related,Autophagy
587871-26-9
C21H17NO3S2
Inhibitors