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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >DNA damage >ATM / ATR inhibitor >3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Structure
CAS No.
1232410-49-9
Chemical Name:
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
Synonyms
VE-821;AVE821;CS-634;VE821;VE 821;ATR Inhibitor IV;VE-821;VE821;VE 821;VE-821 VE821 ATR Inhibitor IV;3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide;3-Amino-6-(4-methanesulfonylphenyl)-N-phenylpyrazine-2-carboxamide;3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide
CBNumber:
CB52534719
Molecular Formula:
C18H16N4O3S
Molecular Weight:
368.41
MOL File:
1232410-49-9.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Properties

Melting point 247-249°C
Boiling point 568.4±50.0 °C(Predicted)
Density 1.394
storage temp. -20°C
solubility Soluble in DMSO (40 mg/ml)
form powder
pka 9.97±0.70(Predicted)
color white to beige
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1415 VE-821 ≥98% (HPLC) 1232410-49-9 5MG ₹11431.2 2022-06-14 Buy
Sigma-Aldrich(India) SML1415 VE-821 ≥98% (HPLC) 1232410-49-9 25MG ₹46547.5 2022-06-14 Buy
Sigma-Aldrich(India) 5.04972 ATR Inhibitor IV - CAS 1232410-49-10 - Calbiochem 1232410-49-9 10MG ₹28169.99 2022-06-14 Buy
Product number Packaging Price Buy
SML1415 5MG ₹11431.2 Buy
SML1415 25MG ₹46547.5 Buy
5.04972 10MG ₹28169.99 Buy

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Chemical Properties,Uses,Production

Description

Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM). It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions. VE-821 also sensitizes cancer cells to chemotherapy.

Chemical Properties

Bright Yellow Solid

Uses

VE 821 is a potent and selective inhibitor of DNA damage response kinase, ATR. VE 821 functions to disrupt DNA damage repair system of tumor cells, limiting their abilities for further growth.

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Suppliers

Global( 136)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide Spectrum

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide(1232410-49-9)1HNMR

1232410-49-9(3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide)Related Search:

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VE-821;VE821;VE 821 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide 2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl- 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide VE-821 VE-821 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide VE821;VE 821 CS-634 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide AVE821 ATR Inhibitor IV 3-Amino-6-(4-methanesulfonylphenyl)-N-phenylpyrazine-2-carboxamide 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide USP/EP/BP VE-821 VE-821 VE821 ATR Inhibitor IV VE 821,ATM and RAD3 related,ATM/ATR,Inhibitor,Ataxia telangiectasia mutated,VE821,VE-821,inhibit 1232410-49-9 Inhibitors API