Pomalidomide
- CAS No.
- 19171-19-8
- Chemical Name:
- Pomalidomide
- Synonyms
- 4-AMino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;CC-4047;Pomadomide;Pomalidomide-d4;PomaL;IMiD 3;CS-388;ActiMid;Pomalidomide;3-dioxo-2-(2
- CBNumber:
- CB32128749
- Molecular Formula:
- C13H11N3O4
- Molecular Weight:
- 273.24
- MOL File:
- 19171-19-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/13 18:00:15
| Melting point | 318.5 - 320.5° |
|---|---|
| Boiling point | 582.9±45.0 °C(Predicted) |
| Density | 1.570±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥14mg/mL |
| pka | 10.75±0.40(Predicted) |
| form | powder |
| color | yellow |
| Merck | 14,135 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18) |
| InChIKey | UVSMNLNDYGZFPF-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C(N)=CC=C2)C(=O)N1C1CCC(=O)NC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360D | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NR3397905 | |||||||||
| HS Code | 29251900 | |||||||||
| NFPA 704 |
|
Pomalidomide price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P0018 | Pomalidomide ≥98% (HPLC) | 19171-19-8 | 5MG | ₹15263.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P0018 | Pomalidomide ≥98% (HPLC) | 19171-19-8 | 25MG | ₹58390.05 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P2074 | Pomalidomide | 19171-19-8 | 25MG | ₹9800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2074 | Pomalidomide | 19171-19-8 | 100MG | ₹14500 | 2022-05-26 | Buy |
Pomalidomide Chemical Properties,Uses,Production
Description
In February 2013, the US FDA approved pomalidomide (also known as CC4047) for the treatment of multiple myeloma (MM) in patients with disease progression after receiving other cancer therapeutics. Pomalidomide is a 4-amino analog of thalidomide with enhanced potency and an improved toxicity profile. Pomalidomide and thalidomide exert their effects by modulation of immunity, inhibition of angiogenesis, interference with the bone/tumor microenvironment, and inhibition of the cereblon protein. Pomalidomide potently inhibited in vitro proliferation in a variety of human MM cell lines, IC50～10 nM, while thalidomide showed almost no inhibition up to 100 μM. In mouse MM tumor models, 50 mg/kg daily doses of pomalidomide resulted in marked inhibition of tumor growth after 15 days of treatment and complete regression in 3–6 weeks versus thalidomide-treated controls at the same dose. Pomalidomide is prepared by condensation of 4-nitrophthalic anhydride with 3-aminopiperidine-2,6-dione followed by catalytic hydrogenation of the nitro group.
Chemical Properties
Yellow Solid
Uses
Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM
Definition
ChEBI: An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.
Pomalidomide Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| MANPICK LABORATORIES PVT LTD | +91-9949460828 +91-9949460828 | Hyderabad, India | 71 | 58 | Inquiry |
| Viyash Life Sciences Pvt Ltd | +91-4023635052 +91-4023635052 | Telangana, India | 213 | 58 | Inquiry |
| Basil Drugs AND Pharmaceuticals Pvt Ltd | +91-2249700250 +91-9619320820 | Mumbai, India | 108 | 58 | Inquiry |
| Triveni Interchem Private Limited | +91-02606618618 +91-7574814001 | Gujarat, India | 42 | 58 | Inquiry |
| NATCO Pharma Limited | +91-9849511345 +91-9866005199 | Hyderabad, India | 24 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Sakar Healthcare | +91-8976292690 +91-9967572302 | Gujarat, India | 47 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
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