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NORFLUOXETINE HYDROCHLORIDE

NORFLUOXETINE HYDROCHLORIDE Structure
CAS No.
57226-68-3
Chemical Name:
NORFLUOXETINE HYDROCHLORIDE
Synonyms
NORFLUOXETINE HCL;Fluoxetine EP Impurity H;NORFLUOXETINE HYDROCHLORIDE;Fluoxetine Impurity 8(EP-H);Norfluoxetine Hydrochloride Solution, 100ppm;Fluoxetine Impurity 8(Fluoxetine EP Impurity H);Norfluoxetine hydrochloride (Desmethylfluoxetine);3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE;3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE;1-(3-Amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene hydrochloride
CBNumber:
CB1112230
Molecular Formula:
C16H17ClF3NO
Molecular Weight:
331.76
MOL File:
57226-68-3.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:09

NORFLUOXETINE HYDROCHLORIDE Properties

storage temp. -20°C
solubility H2O: >4 mg/mL
form solid
color yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
WGK Germany  3

NORFLUOXETINE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Chemical Properties

NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid

Uses

Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant.

NORFLUOXETINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 62)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Allfluoro pharmaceutical co. ltd. 021-26137118 +8615821363818 China 5791 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
China National Standard Pharmaceutical Corporation Limited +8615391658522 China 11927 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Guangzhou Dreampharm Biotechnology Co., Ltd. 020-36607679 17825480238 China 9919 12 Inquiry
NORFLUOXETINE HCL NORFLUOXETINE HYDROCHLORIDE (+/-)-GAMMA-[4-(TRIFLUOROMETHYL)PHENOXY]-BENZENEPROPANAMINE HYDROCHLORIDE 3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE 3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-, hydrochloride 1-(3-Amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene hydrochloride Norfluoxetine Hydrochloride Solution, 100ppm Fluoxetine Impurity 8(EP-H) Fluoxetine EP Impurity H Norfluoxetine hydrochloride (Desmethylfluoxetine) Ca channels,P450,reuptake,Fluoxetine,Norfluoxetine Hydrochloride,CaV3.3,Inhibitor,anticonvulsant,inhibit,CYP2C19,5-HT,N-demethylated,serotonin,Serotonin Receptor,Ca2+ channels,CYP3A4,5-hydroxytryptamine Receptor,Drug Metabolite,Calcium Channel,metabolite,CYP2D6,5-HT Receptor,Norfluoxetine Fluoxetine Impurity 8(Fluoxetine EP Impurity H) 57226-68-3