Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >DNA damage >DNA-PK inhibitors >KU57788(NU7441)

KU57788(NU7441)

KU57788(NU7441) Structure
CAS No.
503468-95-9
Chemical Name:
KU57788(NU7441)
Synonyms
CS-181;NU 7441;KU 57788;KU57788(NU7441);NU-7441 (KU-57788);NU 7441 - KU 47788;KU57788(NU7441) USP/EP/BP;NU7441;KU57788;NU 7441 (KU 57788);NU7441 (KU-57788);KU 57788; NU-7441;NU 7441 (This product is only available in Japan.)
CBNumber:
CB92500947
Molecular Formula:
C25H19NO3S
Molecular Weight:
413.49
MOL File:
503468-95-9.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

KU57788(NU7441) Properties

Melting point 220-221 °C
Boiling point 646.9±55.0 °C(Predicted)
Density 1.376±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble in DMSO (up to 10 mg/ml with warming).
form solid
pka 0.51±0.20(Predicted)
color Off-white to beige
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

KU57788(NU7441) Chemical Properties,Uses,Production

Description

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

KU57788(NU7441) Preparation Products And Raw materials

Raw materials

Preparation Products

KU57788(NU7441) Suppliers

Global( 129)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Fuxin Pharmaceutical +86-021-021-50872116 +8613122107989 China 10297 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Fuxin Pharmaceutical 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58

KU57788(NU7441) Spectrum

KU57788(NU7441)(503468-95-9)1HNMR

503468-95-9(KU57788(NU7441))Related Search:

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Levetiracetam N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) BI 2536 CHLOROPICRIN & ETHYLENE DIBROMIDE
Indole Dibenzofuran Bortezomib NU7026 KU-55933 (ATM Kinase Inhibitor)
VE-821 Ibrutinib Olaparib
chevron_left

1of3

chevron_right
KU57788(NU7441) NU 7441 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one NU7441 (KU-57788);KU 57788; NU-7441 KU 57788 NU-7441 (KU-57788) 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU-7441 NU 7441 (This product is only available in Japan.) CS-181 NU 7441 - KU 47788 NU7441;KU57788;NU 7441 (KU 57788) 8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one KU57788(NU7441) USP/EP/BP 503468-95-9 Inhibitors Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds