CX-4945
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- Product name: CX-4945
- CAS: 1009820-21-6
- MF: C19H12ClN3O2
- MW: 349.77
- EINECS:
- MDL Number:MFCD13184796
- Synonyms:5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid;CX-4945;Silmitasertib;CX-4945 Silmitasertib;CX-4945, CX4945;Silmitasertib(CX-4945);5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib);CX-4945, >=98%
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Properties
Boiling point :568.5±50.0 °C(Predicted)
Density :1.490
storage temp. :Store at -20°C
solubility :≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :Orange powder.
pka :2.96±0.30(Predicted)
color :Yellow to orange
Density :1.490
storage temp. :Store at -20°C
solubility :≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :Orange powder.
pka :2.96±0.30(Predicted)
color :Yellow to orange
Safety Information
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Description
CX-4945 is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki = 0.38 nM) that competes with ATP by filling the small ATP binding site on the catalytic CK2α subunit, conferring selectivity. It inhibits proliferation in a panel of cancer cell lines that overexpress CK2 and prevents tumor growth of breast and pancreatic cancer cell xenografts in mice. CX-4945 blocks survival and induces apoptosis in cancer stem cells and is effective against glioblastomas and acute myeloid leukemia cells. CX-4945 also inhibits Cdc2-like kinases (Clk; IC50s = 82.3, 3.8, and 90 nM for Clk1, Clk2, and Clk3, respectively), interfering with alternative splicing.More related product prices
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![5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid](https://img.chemicalbook.com/ProductImageEN/2019-12/small/6071f2ba-f93d-486f-9cdb-74f52151c90f.png){kind=small}