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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antihypertensive drugs >Pazopanib

Pazopanib

Pazopanib Structure
  • ₹7393.48 - ₹33730.7
  • Product name: Pazopanib
  • CAS: 444731-52-6
  • MF: C21H23N7O2S
  • MW: 437.52
  • EINECS:251-228-4
  • MDL Number:MFCD11616589
  • Synonyms:Pazopanib for research;Pazopanib;Pazopanib(GW786034);5-(4-((2,3-diMethyl-3,3a-dihydro-2H-indazol-6-yl)(Methyl)aMino)pyriMidin-2-ylaMino)-2-MethylbenzenesulfonaMide;5-[(4-{[(2,3-diMethyl-2H-indazol-6-yl)Methyl]aMino}pyriMidin-2-yl)aMino]-2-Methylbenzene-1-sulfonaMide;5-({4-[(2,3-diMethyl-2H-indazol-6-yl)(Methyl)aMino]pyriMidin-2-yl}aMino)-2-MethylbenzenesulfonaMide 5-(4-(N-(2,3-diMethyl-2H-indazole-6-yl)- N-MethylaMino)pyriMidine-2-ylaMino)-2-MethylbenzenesulfonaMide;GW786034; VOTRIENT;BenzenesulfonaMide, 5-[[4-[(2,3-diMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl-
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 25MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberCDS023580
  • Product descriptionPazopanib
  • Packaging25MG
  • Price₹7393.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML3104
  • Product descriptionPazopanib ≥98% (HPLC)
  • Packaging10MG
  • Price₹8356.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML3104
  • Product descriptionPazopanib ≥98% (HPLC)
  • Packaging50MG
  • Price₹33730.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) CDS023580 Pazopanib 25MG ₹7393.48 2022-06-14 Buy
Sigma-Aldrich(India) SML3104 Pazopanib ≥98% (HPLC) 10MG ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) SML3104 Pazopanib ≥98% (HPLC) 50MG ₹33730.7 2022-06-14 Buy

Properties

Melting point :285-289°C (dec.)
Boiling point :728.8±70.0 °C(Predicted)
Density :1.40
Flash point :359℃
storage temp. :Refrigerator
solubility :Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka :10.19±0.60(Predicted)
form :Yellow powder.
color :White to Beige

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P391 Collect spillage. Hazardous to the aquatic environment

Description

Pazopanib is a broad spectrum tyrosine kinase inhibitor that blocks angiogenesis through its actions on VEGF receptors (VEGFRs). It has low nanomolar efficacy against VEGFR1 (FLT1), VEGFR2, VEGFR3 (FLT4), and KIT, as well as receptors for macrophage colony-stimulating factor 1 and platelet-derived growth factor. Pazopanib is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 and, to a lesser extent, CYP1A2 and CYP2C8. It is effective in vivo and is useful in the management of certain types of cancer.

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