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Pazopanib

Pazopanib Structure
CAS No.
444731-52-6
Chemical Name:
Pazopanib
Synonyms
Votrient;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl-benzenesulfonaMide;CS-1857;Pazopanib;Pazopanibr;Pezopanil Hcl;Pazopanib base;Pazopanib, >=99%;GW786034; VOTRIENT
CBNumber:
CB91562449
Molecular Formula:
C21H23N7O2S
Molecular Weight:
437.52
MOL File:
444731-52-6.mol
Modify Date:
2024/5/23 13:54:40
Request For Quotation

Pazopanib Properties

Melting point 285-289°C (dec.)
Boiling point 728.8±70.0 °C(Predicted)
Density 1.40
Flash point 359℃
storage temp. Refrigerator
solubility Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka 10.19±0.60(Predicted)
form Yellow powder.
color White to Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS09
Signal word  Danger
Hazard statements  H360FD-H373-H411
Precautionary statements  P202-P260-P273-P280-P308+P313-P391
Risk Statements  43-62/63
Safety Statements  36/37/39-28B
HS Code  29350090

Pazopanib price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML3104 Pazopanib ≥98% (HPLC) 444731-52-6 10MG ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) SML3104 Pazopanib ≥98% (HPLC) 444731-52-6 50MG ₹33730.7 2022-06-14 Buy
Sigma-Aldrich(India) CDS023580 Pazopanib 444731-52-6 25MG ₹7393.48 2022-06-14 Buy
Product number Packaging Price Buy
SML3104 10MG ₹8356.9 Buy
SML3104 50MG ₹33730.7 Buy
CDS023580 25MG ₹7393.48 Buy

Pazopanib Chemical Properties,Uses,Production

Description

Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay). It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs. It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.

Chemical Properties

Off-White Solid

Characteristics

Class: receptor tyrosine kinase
Treatment: RCC, STS
Oral bioavailability = 14–39%
Elimination half-life = 31 h
Protein binding > 99.9%

Uses

Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

Definition

ChEBI: A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.

Pazopanib Preparation Products And Raw materials

Raw materials

Preparation Products

Pazopanib Suppliers

Global( 414)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
Molkem Chemicals +91-917228022464 +91-7228022464 Ahmedabad, India 138 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Laurus Labs Ltd +91-4066594333 +91-4039804333 Telangana, India 50 58 Inquiry
Shreyaa Medilife Private Limited +91-6354474696 +91-9879513108 Ahmedabad, India 67 58 Inquiry
Aspen Biopharma Labs Pvt Ltd +91-9248058660 +91-9248058662 Telangana, India 234 58 Inquiry
Granules India Limited +91-4069043500 +91-4069043500 Telangana, India 30 58 Inquiry
LAURUS LABS LIMITED +91 891 306 1222 New Delhi, India 32 58 Inquiry
Anzen Exports 91-33-24548159 Kolkata, India 164 58 Inquiry
HRV Global Life Sciences Private Limited 91-40-23554991 Hyderabad, India 190 58 Inquiry
Supplier Advantage
Dr. Reddy's Laboratories Ltd 58
Molkem Chemicals 58
HRV Global Life Sciences 58
Laurus Labs Ltd 58
Shreyaa Medilife Private Limited 58
Aspen Biopharma Labs Pvt Ltd 58
Granules India Limited 58
LAURUS LABS LIMITED 58
Anzen Exports 58
HRV Global Life Sciences Private Limited 58

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Pazopanib Spectrum

Pazopanib(444731-52-6)1HNMR

444731-52-6(Pazopanib)Related Search:

3-Methyl-6-nitroindazole N,N-Dimethylformamide p-Toluenesulfonamide Dacthal Sulfanilamide
3-Aminobenzenesulfonamide Xylene Dimethyl sulfoxide Dimethyl sulfate Dimethyl phthalate
Dimethyl fumarate Benzenesulfonamide Dimethyl carbonate N,N-Dimethyl-1,4-phenylenediamine ETHANE
Dimethyl ether N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
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Pazopanib for research Pazopanib Pazopanib(GW786034) 5-(4-((2,3-diMethyl-3,3a-dihydro-2H-indazol-6-yl)(Methyl)aMino)pyriMidin-2-ylaMino)-2-MethylbenzenesulfonaMide 5-[(4-{[(2,3-diMethyl-2H-indazol-6-yl)Methyl]aMino}pyriMidin-2-yl)aMino]-2-Methylbenzene-1-sulfonaMide 5-({4-[(2,3-diMethyl-2H-indazol-6-yl)(Methyl)aMino]pyriMidin-2-yl}aMino)-2-MethylbenzenesulfonaMide 5-(4-(N-(2,3-diMethyl-2H-indazole-6-yl)- N-MethylaMino)pyriMidine-2-ylaMino)-2-MethylbenzenesulfonaMide GW786034; VOTRIENT BenzenesulfonaMide, 5-[[4-[(2,3-diMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl- Pazopanib base Votrient(pazopanib) 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Pazopanib Pazopanib 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Pazopanib, >=99% 5-[4-[(2,3-Dimethyl-2H-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino]-2-methyl-benzenesulfon CS-1857 Pazopanib (free base) (GW786034, Votrient) Pazopanib USP/EP/BP Pazopanibr 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide PazopanibQ: What is Pazopanib Q: What is the CAS Number of Pazopanib Q: What is the storage condition of Pazopanib Q: What are the applications of Pazopanib 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Votrient 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl-benzenesulfonaMide Palmer azole panitan Pezopanil Hcl 444731-52-6 C21H23N7O2S Inhibitors HFC80010 Intermediates & Fine Chemicals Pharmaceuticals API API 444731-52-6