ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
![N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Structure](CAS/GIF/444731-75-3.gif)
- CAS No.
- 444731-75-3
- Chemical Name:
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- Synonyms
- BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin...
- CBNumber:
- CB02526159
- Molecular Formula:
- C14H14ClN5
- Molecular Weight:
- 287.75
- MOL File:
- 444731-75-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/6 16:20:44
Melting point | 167-173℃ |
---|---|
Boiling point | 524.4±35.0 °C(Predicted) |
Density | 1.33±0.1 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
pka | 2.82±0.30(Predicted) |
Stability | Hygroscopic |
CAS DataBase Reference | 444731-75-3 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
NFPA 704 |
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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties,Uses,Production
Chemical Properties
Light Beige to Beige Solid
Uses
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Synthesis
A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 194)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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Kalam Sai Life Sciences Pvt Ltd | +919849478888 | Hyderabad, India | 73 | 58 | Inquiry |
Litha Life Sciences Pvt Limited | +91-9849999500 +91-9849999500 | Hyderabad, India | 29 | 58 | Inquiry |
Lakshana Biotechnologies Private Limited | +91-9010404655 +91-9010404655 | Hyderabad, India | 20 | 58 | Inquiry |
Vidgas science and technologies Pvt Ltd | +91-9030019844 +91-9030019844 | Telangana, India | 76 | 58 | Inquiry |
ANAXLABORATORIES PRIVATE LIMITED | +91-9177075735 | Telangana, India | 686 | 58 | Inquiry |
Stereokem Pvt Ltd | +91-4029706929 +91-9394224843 | Telangana, India | 350 | 58 | Inquiry |
Synergene Active Ingredients Pvt. Ltd. | +91-04023700774 +91-04023700774 | Telangana, India | 96 | 58 | Inquiry |
ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
Kekule Pharma Limited | +919849798889 | Hyderabad, India | 59 | 58 | Inquiry |
Raising Sun Pharma | +91-9399941155 +91-9399941155 | Telangana, India | 127 | 58 | Inquiry |
444731-75-3(N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine)Related Search:
1,3-DiMethyl-6-aMino-1H-indazole
4(1H)-Pyrimidinone, 2-chloro- (9CI)
5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide
2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
5-BROMO-3-METHYLINDOLE
Pazopanib Impurity 10
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
Pazopanib-d6
2,3-dimethyl-2H-indazol-6-amine hydrochloride
Pazopanib Impurity 9
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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine
2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-
6-[N-(2-chloro-4-pyriMidinyl)MethylaMino]-2,3-diMethyl-2H-indazole, 96%
N-(2-ChloropyriMidin-4-yl)-N-Methyl-2,3-diMethyl-2H-indazol-6-aMine
2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine
BNKY007-PZ02
2H-indazole-6-aMine,N-(2-chloro
-4-pyrimidinyl)-N,2,3-trimethyl-
Pazopanib Impurity 22
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine
N-(2- chloropyrimidine-4- group)- N- methyl-2,3-dimethyl-2 H- indazole-6-amine
6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole,96%
N-(2-chloropyrimidine-4-yl) -N-methyl-2, 3-dimethyl-2H-indazol-6-amine
Pazopanib intermediate
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine ISO 9001:2015 REACH
(2-Chloro-pyrimidin-4-yl)-(2,3-dimethyl-2H-indazol-6-yl)-methyl-amine
N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin...
TIANFU-CHEM - N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
Pazopanib ( PAZ ) N - Methyl compound
444731-75-3
44731-75-3