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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

CAS No.: 444731-75-3

Chemical Name:: N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

Synonyms: BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin...

CBNumber:: CB02526159

Molecular Formula:: C14H14ClN5

Molecular Weight:: 287.75

MOL File:: 444731-75-3.mol

MSDS File:: SDS

Modify Date:: 2024/6/6 16:20:44

Request For Quotation

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Properties

Melting point	167-173℃
Boiling point	524.4±35.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
pka	2.82±0.30(Predicted)
Stability	Hygroscopic
CAS DataBase Reference	444731-75-3

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

NFPA 704

	1
2		0

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties,Uses,Production

Chemical Properties

Light Beige to Beige Solid

Uses

N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Synthesis

A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials

Raw materials

2H-Indazol-6-amine, N,2,3-trimethyl- N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 2,4-Dichloropyrimidine Iodomethane

Preparation Products

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Suppliers

Global( 194)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Kalam Sai Life Sciences Pvt Ltd	+919849478888	Hyderabad, India	73	58	Inquiry
Litha Life Sciences Pvt Limited	+91-9849999500 +91-9849999500	Hyderabad, India	29	58	Inquiry
Lakshana Biotechnologies Private Limited	+91-9010404655 +91-9010404655	Hyderabad, India	20	58	Inquiry
Vidgas science and technologies Pvt Ltd	+91-9030019844 +91-9030019844	Telangana, India	76	58	Inquiry
ANAXLABORATORIES PRIVATE LIMITED	+91-9177075735	Telangana, India	686	58	Inquiry
Stereokem Pvt Ltd	+91-4029706929 +91-9394224843	Telangana, India	350	58	Inquiry
Synergene Active Ingredients Pvt. Ltd.	+91-04023700774 +91-04023700774	Telangana, India	96	58	Inquiry
ALS INDIA LIFE SCIENCES	+91-8977036379 +91-8977036379	Hyderabad, India	1879	58	Inquiry
Kekule Pharma Limited	+919849798889	Hyderabad, India	59	58	Inquiry
Raising Sun Pharma	+91-9399941155 +91-9399941155	Telangana, India	127	58	Inquiry

Supplier	Advantage
Kalam Sai Life Sciences Pvt Ltd	58
Litha Life Sciences Pvt Limited	58
Lakshana Biotechnologies Private Limited	58
Vidgas science and technologies Pvt Ltd	58
ANAXLABORATORIES PRIVATE LIMITED	58
Stereokem Pvt Ltd	58
Synergene Active Ingredients Pvt. Ltd.	58
ALS INDIA LIFE SCIENCES	58
Kekule Pharma Limited	58
Raising Sun Pharma	58

444731-75-3(N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine)Related Search:

1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 5-BROMO-3-METHYLINDOLE

Pazopanib Impurity 10 N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Impurity 9

Pazopanib 3-Methyl-6-nitro-2H-indazole Pazopanib Related Compound 3 1,3-Dimethyl-6-nitro-1H-indazole Pazopanib Related Compound 2

(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid 4-Acetoxy-3-acetoxymethylacetophenone

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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl- 6-[N-(2-chloro-4-pyriMidinyl)MethylaMino]-2,3-diMethyl-2H-indazole, 96% N-(2-ChloropyriMidin-4-yl)-N-Methyl-2,3-diMethyl-2H-indazol-6-aMine 2,3-dimethyl-N-(2-chloropyrimidin-4-yl)-N-methyl-2H-indazol-6-amine BNKY007-PZ02 2H-indazole-6-aMine，N-(2-chloro -4-pyrimidinyl)-N,2,3-trimethyl- Pazopanib Impurity 22 N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine N-(2- chloropyrimidine-4- group)- N- methyl-2,3-dimethyl-2 H- indazole-6-amine 6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole,96% N-(2-chloropyrimidine-4-yl) -N-methyl-2, 3-dimethyl-2H-indazol-6-amine Pazopanib intermediate N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine ISO 9001：2015 REACH (2-Chloro-pyrimidin-4-yl)-(2,3-dimethyl-2H-indazol-6-yl)-methyl-amine N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amin... TIANFU-CHEM - N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Pazopanib ( PAZ ) N - Methyl compound 444731-75-3 44731-75-3