ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- CAS No.
- 28416-82-2
- Chemical Name:
- (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
- Synonyms
- FluMethasone acid;Fluticasone Acid;Axon 1170;impurity J;BNKY011-FP01;BNKY012-FF01;Flumetasone acid;flumethason acid;(6a,11b,16a,17a)-6;17-carboxylic acid
- CBNumber:
- CB2854948
- Molecular Formula:
- C21H26F2O5
- Molecular Weight:
- 396.42
- MOL File:
- 28416-82-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/29 22:56:24
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Properties
| Melting point | 303-305°C |
|---|---|
| Boiling point | 568.4±50.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.49±0.70(Predicted) |
| color | White to Off-White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2937220000 |
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Chemical Properties,Uses,Production
Description
Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid fluticasone propionate .
Chemical Properties
White Solid
Uses
Fluticasone intermediate. Anti-inflammatory agent
General Description
Fluticasone 17β-carboxylic acid ((6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid) is a compound of interest in studying structure-activity relationships within corticosteroid analogs. In research, this compound is examined for its potential interactions with glucocorticoid receptors, given its structural similarity to fluticasone, which is known for its affinity to these receptors. The 17β-carboxylic acid moiety may alter the compound's binding characteristics. In biochemistry, fluticasone 17β-carboxylic acid is used to probe the metabolic pathways of fluticasone, as it may be a metabolite or intermediate.
Synthesis
To a suspension of flumethasone (1.19 g, 2.9 mmol) in tetrahydrofuran (11 ml) was added a solution of periodic acid (2.25 g, 9.9 mmol) in water (5.3 ml). The resulting solution was stirred at RT for 1 h. The tetrahydrofuran was removed in vacuo to leave an aqueous suspension which was filtered, and the solid washed with water and dried to give 1.17 g (100%) of the (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (Fluticasone 17β-Carboxylic Acid) as a colorless solid.
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid Preparation Products And Raw materials
Global( 217)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Hemarsh Technologies | 08068441092Ext 237 | Vadodara, India | 23 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Olympus Chemicals & Fertilizers | 08068441058Ext 121 | Maharashtra, India | 486 | 58 | Inquiry |
| BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 | China | 52 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
28416-82-2((6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid)Related Search:
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6a,9a-Difluoro-11b,17a-dihydroxy-16a-methylpregna- 3-oxo-1,4-diene-17b-carboxylic Acid
Fluticasone 17b-Carboxylic Acid
6A,9A-DIFLUORO-11SS,17A-DIHYDROXY-3-OXOANDROSTA-1,4-DIENE-17SS-CARBOXYLIC ACID
ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6ALPHA,11BETA,16ALPHA,17ALPHA)-
ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6A,11SS,16A,17A)-
(6a,11,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
6a,9a-Difluoro-11,17a-dihydroxy-16a-methylpregna-3-oxo-1,4-diene-17-carboxylic Acid
Fluticasone 17-Carboxylic Acid
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-M
6a,9a-difluoro-11 P,17a-dihydroxy-16a-methyl-3-
oxoandrosta-1,4-diene-17P-carboxylic acid
6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid
Discontinued see product # F599490
Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17- dihydroxy-16-Methyl-3-oxo-,(6|á,11|,16|á,17|á)-
(6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-Methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
6α,9α-Difluoro-11β,17α-dihydroxy-16α-Methylpregna-
3-oxo-1,4-diene-17β-carboxylic Acid
(6A,11B,16A,17A)-6,9-DIFLUORO-11,17-diHYDROXY-16-METHY1-3-OXOANDROSTA-1,4-DIENE-17-CAR
(6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-DIFLUORO-11,17-DIHYDRO
Fluticasone propionate Intermediates (Flumethasone acid)
Fluticasone Carboxylic Acid
(6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
(6a,9a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxyl
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID,6,9-DIFLUORO-11,17- DIHYDROXY-16-METHYL-3-OXO-,(6α,11β,16α,17α)-
6a,9a-Difluoro-1117a-dihydroxy-3-oxoandrosta-1,4-diene-17carboxylic Acid Discontinued see product # F599490
Axon 1170
impurity J
6α,9-Difluoro-11β-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17β-carboxylic acid
Fluticasone Impurity 11(Fluticasone USP RC J)
Fluticasone USP RC J
Fluticasone 17-beta-Carboxylic Acid
BNKY011-FP01
BNKY012-FF01
Propionate Impurity J
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid
(6S,8S,9R,10S,11S,13S,14S,16R,17R)
Fluticasone USP Related Compound J
Fluticasone IMpurity J
Fluticasone Propionate Impurity 1
1,4-diene-17-carboxylic acid
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid [Flumethasone Acid]
6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid Discontinued see product # F599490
Fluticasone 17β-Carboxylic Acid
Flumetasone acid
FLUMETHASONE ACID /CAS NO.:28416-82-2
6α,9α-Difluoro-11β-,17α-dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic Acid
Discontinued see F599490
6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid
Fluticasone Related Compound J
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-ox...
Androsta-1,4-diene-17-carboxylic acid,6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6a,11b,16a,17a)-
(6S,9R,10S,11S,13S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid
Fluticasone Propionate Related Compound J (6alpha, 9alpha-difluoro-11beta,17alpha-dihydroxy-16alpha (1285818)
FluMethasone acid
Fluticasone Acid
flumethason acid
Fluticasone Propionate USP Related Compound J
(6a,11b,16a,17a)-6
Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-
Fluticasone Propionate Impurity 6