ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Endocrinology & Hormones >Glucocorticoid Receptor agonists >Flumethasone
Flumethasone
- CAS No.
- 2135-17-3
- Chemical Name:
- Flumethasone
- Synonyms
- fluvet;FLUCORT;rs-2177;ANIPRIME;anaprime;methagon;NSC-54702;CORTEXILAR;ha-methyl-;umethasone
- CBNumber:
- CB2324823
- Molecular Formula:
- C22H28F2O5
- Molecular Weight:
- 410.45
- MOL File:
- 2135-17-3.mol
- Modify Date:
- 2024/11/21 15:02:05
| Melting point | 237-240°C |
|---|---|
| Boiling point | 569.8±50.0 °C(Predicted) |
| Density | 1.1621 (estimate) |
| storage temp. | 2-8°C |
| solubility | acetic acid: soluble10mg/mL |
| form | solid |
| pka | 11.98±0.70(Predicted) |
| color | white |
| optical activity | [α]25/D 67.0 to 71.0°, c = 1 in dioxane |
| Water Solubility | 1mg/L(20 ºC) |
| Merck | 14,4138 |
| InChIKey | WXURHACBFYSXBI-GQKYHHCASA-N |
| CAS DataBase Reference | 2135-17-3(CAS DataBase Reference) |
Flumethasone Chemical Properties,Uses,Production
Description
Flumethasone is an agonist of glucocorticoid and mineralocorticoid receptors with EC50 values of 0.26 and 0.494 nM, respectively, in CV-1 cells expressing human receptors. In vitro, it inhibits the growth of UM-UC-3, TCC-SUP, and 5637 urothelial carcinoma cell lines at a concentration of 100 nM. Flumethasone (5 mg per animal) decreases tumor necrosis factor (TNF) production ex vivo in blood cells collected by bronchoalveolar lavage (BAL) from calves with experimentally-induced local lung inflammation. It also inhibits phytohemagglutinin-induced delayed hypersensitivity in calf skin. In vivo, flumethasone (5 μM) impairs cell cycle re-entry of cardiac cells seven days post cryo-injury to the heart and impairs cardiac regeneration in zebrafish.
Chemical Properties
White Solid
Flumethasone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 431)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JIVICHEM SYNTHESIS PVT LTD | +91-7028392790 +91-7028392790 | Maharashtra, India | 335 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Avik Pharmaceutical Limited | +91-9821827247 +91-7600019006 | Maharashtra, India | 22 | 58 | Inquiry |
| Symbiotec Pharma Lab Pvt Ltd | +91-7316676406 +91-7316676405 | Madhya Pradesh, India | 71 | 58 | Inquiry |
| Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 526 | 58 | Inquiry |
| Uni-Chemie International | 91-22-28881114 | Maharashtra, India | 62 | 58 | Inquiry |
| Orient Pharma | 91-22-66976686 | Maharashtra, India | 204 | 58 | Inquiry |
| Thykn (India) International | 91-22-67033666 | Maharashtra, India | 89 | 58 | Inquiry |
| Ralington Pharma. | 91-79-48911722 | Gujarat, India | 311 | 58 | Inquiry |
| Sign Pharma Trade Services Pvt., Ltd.(SPTS) | 91-22-23481235 | Mumbai, India | 160 | 58 | Inquiry |
2135-17-3(Flumethasone)Related Search:
flumethasone-17-acetate,Flumethasone21-acetate
Methylparaben
Methyl acrylate
Kresoxim-methyl
Bensulfuron methyl
Dexamethasone
Betamethasone
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
Fluorometholone
Methylprednisolone
chevron_left
1of4
chevron_right
6-alpha,9-alpha-difluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
6α,9α-Difluoro-16α-methylprednisolone
6α-Fluorodexamethasone
6a-Fluoro-dexamethasone, Aniprime, Cortexilar, Flucort
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-
6α,9α-difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
FlumethasoneBase98.5%
(6-alpha,11-beta,16-alpha)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Flumethazone
flumetasone
CORTEXILAR
FLUCORT
FLUMETHASONE
ANIPRIME
6a,9a-difluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione
6a,9a-difluoro-16a-methylprednisolone
6A-FLUORO-DEXAMETHASONE
6ALPHA,9ALPHA-DIFLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
6ALPHA,9ALPHA-DIFLUORO-16ALPHA-METHYLPREDNISOLONE
6ALPHA-FLUORODEXAMETHASONE
1,4-PREGNADIEN-6-ALPHA, 9-ALPHA-DIFLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
anaprime
flucorticin
flumethason
fluvet
ha-methyl-
methagon
rs-2177
6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone, 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Cortexillar
NSC-54702
Flumethasone,6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone
FluMetahsone
FULUMETHASONE
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
Flumethasone Solution, 100ppm
Flumetasone (double dexamethasone)
Flumethasone, >=99%
3-(4-methylpent-3-enyl)-2,5-dihydrothiophene 1,1-dioxide
lumethasone
Flumetazone
Flumethasone sky
flumetasone cas: 2135-17-3
6alpha,9-Difluoro-11beta,17,21-trih
umethasone
Pregna-1,4-diene-3,20-dione,6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)-
Flumethasone USP/EP/BP
Flumethasone 2135-17-3
Flumetasone pivalate EP Impurity A
Flumethasone (Flumetasone)
6alpha,9-Difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione (Flumetasone)
(6S,8S,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
1, 4-PREGNADIEN-6α, 9α-DIFLUORO-16α-METHYL-11β, 17, 21-TRIOL-3, 20-DIONE
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
C13718500 Flumethasone
Flumethasone in Acetonitrile
Flumethasone, 10 mM in DMSO
2135-17-3