ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Adrenal corticosteroids >Betamethasone
Betamethasone
- CAS No.
- 378-44-9
- Chemical Name:
- Betamethasone
- Synonyms
- Betamethason;C22H29O5F;Betametasone;betamethasone standard;Dermabet;Celestone;FLUBENISOLONE;17,21-trihydr;Dexamethasone EP Impurity B;Bifas
- CBNumber:
- CB7392335
- Molecular Formula:
- C22H29FO5
- Molecular Weight:
- 392.47
- MOL File:
- 378-44-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/25 20:04:51
| Melting point | 235-237°C |
|---|---|
| alpha | D +108° (acetone) |
| Boiling point | 568.2±50.0 °C(Predicted) |
| Density | 1.1283 (estimate) |
| refractive index | 118 ° (C=1, Dioxane) |
| storage temp. | 0-6°C |
| solubility | Practically insoluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride. |
| form | Solid |
| pka | 12.13±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | 58mg/L(25 ºC) |
| Merck | 14,1180 |
| LogP | 2.01 at 25℃ |
| CAS DataBase Reference | 378-44-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9) |
| EPA Substance Registry System | Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.beta.)- (378-44-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H373 |
| Precautionary statements | P202-P260-P280-P308+P313-P405-P501 |
| Hazard Codes | Xi,Xn,T |
| Risk Statements | 40-48/20/21-61 |
| Safety Statements | 22-36-45-53 |
| WGK Germany | 2 |
| RTECS | TU4000000 |
| HS Code | 29379000 |
| Toxicity | LD50 oral in mouse: > 4500mg/kg |
Betamethasone price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B9675 | Betamethasone meets USP testing specifications | 378-44-9 | 25MG | ₹6462.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1398 | Betamethasone Pharmaceutical Secondary Standard; Certified Reference Material | 378-44-9 | 1G | ₹9894.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9675 | Betamethasone meets USP testing specifications | 378-44-9 | 100MG | ₹21628.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B7005 | Betamethasone ≥98% | 378-44-9 | 100MG | ₹23111.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B7005 | Betamethasone ≥98% | 378-44-9 | 500MG | ₹80743.68 | 2022-06-14 | Buy |
Betamethasone Chemical Properties,Uses,Production
Description
Shortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active. Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest that it is best used for short-term therapy.
Chemical Properties
White to Off-White Solid
Uses
Betamethasone is a glucocorticoid used as an anti-inflammatory agent.
General Description
Betamethasone, 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,is available as a variety of ester derivatives.
Betamethasone valerate, USP (17-valerate)
Betamethasone acetate, USP (21-acetate)
Betamethasone sodium phosphate, USP (21-sodiumphosphate)
Betamethasone dipropionate, USP (17-propionate,21-propionate).
Side effects
Toxic side effects, such as increased appetite, weight gain, and facial mooning, occur with prolonged use.
Safety Profile
Low toxicity by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes of F-.
Purification Methods
Betamethasone crystallises from ethyl acetate, and has max at 238nm (log 4.18) in MeOH. The 21-acetate [287-24-6] crystallises from Me2CO/Et2O (charcoal) m 196-201o (205-208o) and has [] D 20 +140o (CHCl3). [Taub et al. J Am Chem Soc 82 4012 1960, Olivetto et al. J Am Chem Soc 80 6688 1958, Beilstein 8 IV 3501.]
Betamethasone Preparation Products And Raw materials
Raw materials
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| Supplier | Advantage |
|---|---|
| OPULENT PHARMA | 58 |
| SynThink RESEARCH CHEMICALS | 58 |
| Medi Pharma Drug House | 58 |
| Chempifine Chemicals | 58 |
| Prachem Laboratories | 58 |
| Envee Drugs Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| Horster Biotek Pvt Ltd | 58 |
| Symbiotec Pharma Lab Pvt Ltd | 58 |
| Unimax Chemicals Pvt Ltd | 58 |
378-44-9(Betamethasone)Related Search:
Betamethasone valerate impurity A (PhEur)
Betamethasone solution,100ppm
(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
BETAMETHASONE
BETADEXAMETHASONE
(11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
16-beta-methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20
16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione
17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-9-alpha-fluoro-11-bet
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Betamethasone Base & Salts
Betamethasone,9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone
Betamethasone (200 mg)
BetaMethasone (Celestone)
BetaMethasone SolutioM
Betacortil
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,13,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3(9H,10H,14H)-one
6beta)-
9-alpha-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
Cidoten
Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16beta-methyl-
Desacort-beta
Hormezon
Methazon
NSC-39470
Prednisolone, 9-fluoro-16beta-methyl-
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-
pregna-1,4-diene-3,20-dione,9-fluoro-11,17,21-trihydroxy-16-methyl-,(11beta,1
Rinderon
Visubeta
BETAMETHASONE(RG)
24: PN: US20030109453 SEQID: 23 claimed sequence
9-Fluoro-11b,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
9-Fluoro-16β-methylprednisolone
9α-Fluoro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
9α-Fluoro-16β-methylprednisolone
Bedifos
Bifas
Celeston
Colircusi betamida
Diprospan
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-
Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-16β-methyl- (8CI)
Rinderon A
β-Methasone
β-Methasone alcohol
9α-Fluoro-16β-methylprednisolone, 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Betalon
NoReumar
Novocort
Pertene
9a-Fluoro-16-methylprednisolone
(11beta,16beta)-9-Fluro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-beta-methylpregna-1,4-diene
9-alpha-fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20
9-alpha-Fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione