베타메타손
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베타메타손 속성
- 녹는점
- 235-237°C
- 알파
- D +108° (acetone)
- 끓는 점
- 568.2±50.0 °C(Predicted)
- 밀도
- 1.1283 (estimate)
- 굴절률
- 118 ° (C=1, Dioxane)
- 저장 조건
- 0-6°C
- 용해도
- 물에 거의 녹지 않고, 무수 에탄올에 거의 녹지 않으며, 염화메틸렌에 아주 약간 녹습니다.
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 12.13±0.70(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- 58mg/L(25℃)
- Merck
- 14,1180
- LogP
- 2.01 at 25℃
- CAS 데이터베이스
- 378-44-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn,T | ||
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위험 카페고리 넘버 | 40-48/20/21-61 | ||
안전지침서 | 22-36-45-53 | ||
WGK 독일 | 2 | ||
RTECS 번호 | TU4000000 | ||
HS 번호 | 29379000 | ||
유해 물질 데이터 | 378-44-9(Hazardous Substances Data) | ||
독성 | LD50 oral in mouse: > 4500mg/kg |
그림문자(GHS): | |||||||||||||||
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신호 어: | Danger | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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베타메타손 C화학적 특성, 용도, 생산
개요
Shortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active. Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest that it is best used for short-term therapy.화학적 성질
White to Off-White Solid용도
Betamethasone is a glucocorticoid used as an anti-inflammatory agent.일반 설명
Betamethasone, 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,is available as a variety of ester derivatives.Betamethasone valerate, USP (17-valerate)
Betamethasone acetate, USP (21-acetate)
Betamethasone sodium phosphate, USP (21-sodiumphosphate)
Betamethasone dipropionate, USP (17-propionate,21-propionate).
부작용
Toxic side effects, such as increased appetite, weight gain, and facial mooning, occur with prolonged use.Safety Profile
Low toxicity by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes of F-.Purification Methods
Betamethasone crystallises from ethyl acetate, and has max at 238nm (log 4.18) in MeOH. The 21-acetate [287-24-6] crystallises from Me2CO/Et2O (charcoal) m 196-201o (205-208o) and has [] D 20 +140o (CHCl3). [Taub et al. J Am Chem Soc 82 4012 1960, Olivetto et al. J Am Chem Soc 80 6688 1958, Beilstein 8 IV 3501.]베타메타손 준비 용품 및 원자재
원자재
베타메타존21-아세테이트
염산
6베타-하이드록시베타메타손17-프로피오네이트
Betamethasone 17,21-dipropionate
6-하이드록시베타메타손
9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
준비 용품
베타메타손 공급 업체
글로벌( 692)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 |
Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 |
ably@aljbio.com | China | 145 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 |
Nancy@kangcang.com.cn | China | 341 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2989 | 55 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |
베타메타손 관련 검색:
4-하이드록시벤조 산( 히드록실아파타이트 2-히드록시페닐아세트산 글리콜산 메틸파라벤 4-히드록시벤즈알데히드 포름알데히드 시아노히드린 베타메타손
Methylprednisolone
Hydroxy silicone oil
Beclomethasone dipropionate
Budesonide
Betamethasone 21-phosphate,Betamethasone phosphate
Betamethasone 17,21-dipropionate
Betamethasone 17-valerate
BETAMETHASONE 21-PHOSPHATE DISODIUM SALT
16-beta Methyl Epoxide
Dexamethasone 21-phosphate disodium salt