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Betamethasone 17-valerate

Betamethasone 17-valerate Structure
CAS No.
2152-44-5
Chemical Name:
Betamethasone 17-valerate
Synonyms
BETAMETHASONE VALERATE;VALISONE;Betaderm;BETNOVATE;BETHAMETASONE VALERATE;Luxiq;Betoid;Valison;9α-Fluo;Deviphos
CBNumber:
CB1317879
Molecular Formula:
C27H37FO6
Molecular Weight:
476.58
MOL File:
2152-44-5.mol
MSDS File:
SDS
Modify Date:
2024/8/8 18:06:34

Betamethasone 17-valerate Properties

Melting point 183-184°
alpha D +77° (dioxane)
Boiling point 598.9±50.0 °C(Predicted)
Density 1.1174 (estimate)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
form Solid
pka 12.90±0.70(Predicted)
color White
Merck 13,1183
BRN 4240001
InChIKey SNHRLVCMMWUAJD-SUYDQAKGSA-N
SMILES [C@]12(C)C[C@@H]([C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@@]3([H])[C@]1([H])C[C@H](C)[C@@]2(C(=O)CO)OC(=O)CCCC)O |&1:0,3,4,6,16,18,21,23,r|
CAS DataBase Reference 2152-44-5(CAS DataBase Reference)
EPA Substance Registry System .beta.-Methasone 17-valerate (2152-44-5)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360D-H373
Precautionary statements  P201-P202-P260-P280-P308+P313-P405
Hazard Codes  Xn
Risk Statements  48
Safety Statements  22-24/25
RTECS  TU3835000
HS Code  2937229000
Toxicity mouse,LD50,intraperitoneal,632mg/kg (632mg/kg),Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
NFPA 704
0
4 0

Betamethasone 17-valerate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) B0515 Betamethasone 17-valerate 2152-44-5 25MG ₹10294.58 2022-06-14 Buy
Sigma-Aldrich(India) B0515 Betamethasone 17-valerate 2152-44-5 100MG ₹28209.95 2022-06-14 Buy
Sigma-Aldrich(India) PHR1780 Betamethasone Valerate Pharmaceutical Secondary Standard; Certified Reference Material 2152-44-5 1G ₹28383.15 2022-06-14 Buy
Sigma-Aldrich(India) B0515 Betamethasone 17-valerate 2152-44-5 500MG ₹86361.85 2022-06-14 Buy
Sigma-Aldrich(India) 46074 Betamethasone 17-valerate VETRANAL?, analytical standard 2152-44-5 250MG ₹8779.08 2022-06-14 Buy
Product number Packaging Price Buy
B0515 25MG ₹10294.58 Buy
B0515 100MG ₹28209.95 Buy
PHR1780 1G ₹28383.15 Buy
B0515 500MG ₹86361.85 Buy
46074 250MG ₹8779.08 Buy

Betamethasone 17-valerate Chemical Properties,Uses,Production

Description

Betamethasone 17-valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone. Betamethasone 17-valerate is often used to treat mild eczema with good efficacy and lower incidence of steroid induced adverse effects due to its lower potency compared to other glucocorticoids. It is available in cream, ointment, lotion, and foam preparations for topical use.

Chemical Properties

White Solid

Uses

Betamethasone 17-Valerate is a glucocorticoid with anti-inflammatory properties and immunosuppressive activity. It is an antiepileptic non-selective phosphodiesterase inhibitor. Topical application of Betamethasone 17-Valerate has been shown to inhibit heat-induced vasodilatation in man. As a medium-strength corticosteroid, this medication is used to treat a variety of skin conditions (such as eczema, dermatitis, allergies, rash). Betamethasone reduces the swelling, itching, and redness that can occur in these types of conditions.

Indications

Betamethasone valerate (Psorion, Beta-Val, Luxiq) is a synthetic fluorinated corticosteroid.

Definition

ChEBI: Betamethasone valerate is a steroid ester that is betamethasone in which the hydroxy group at the 17alpha position has been converted to the corresponding pentanoate ester. It has a role as an anti-inflammatory drug. It is a steroid ester, a 20-oxo steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a primary alpha-hydroxy ketone. It is functionally related to a betamethasone.

Betamethasone 17-valerate Preparation Products And Raw materials

Raw materials

Preparation Products

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pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopenty 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate 9ALPHA-FLUORO-16BETA-METHYLPREDNISOLONE 17-VALERATE 9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17-VALERATE 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE 1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate 9α-Fluoro-16β-methylprednisolone 17-valerate, Betnovate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate BetaMethasone valerate (Betnovate) BetaMethasone Valerate, Micronized USP Deviphos Phosphanylidenezinc zinc Valison [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate valeric acid [(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-17-glycoloyl-11-hydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester Betamethasone 17-valerate,1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 9α-Fluoro-16β Betamethasone Valerate (200 mg) Betamethasone Valerate (200 mg)K0C3300.997mg/mg(ai) Betamethasone 17-val BetaMethasone valerate (Betnovate, Celestone) (11β,16β)-9-Fluoro-11,21-dihydroxy-16-Methyl-17-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione 9α-Fluo 9α-Fluoro-16β-Methylprednisolone 17-Valerate (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-triMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate BetaMethasone valerate 17- betnovateat celestoderm 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 17-VALERATE BEDERMIN BETNESOL-V BETNEVAL BETAMETHASONE 17ALPHA-VALERATE BETAMETHASONE 17A-VALERATE BETAMETHASONE 17-VALERATE BETAMETHASONEVALERATE,MICRONIZEDPOWDER,USP 9α-Fluoro-11β,21-dihydroxy-16β-methyl-17α-valeryloxypregna-1,4-diene-3,20-dione Beta-Val Betoid Bextasol Celestan V Celestane V Celestoderm V Celeston valerate Dermosol Dermovaleas Ecoval 70 Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 17-valerate (7CI, 8CI) Rinderon V Stanoval Tokuderm Valeric acid, 17-ester with 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione (8CI) betamethasone pentanoate 1,4-pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate BETAMETHASONE 17-VALERATE VETRANAL, 250 BETAMETHASONE 17-VALERATE BP USP BETAMETHASONE VALERATE BP STANDARD(CRM STANDARD) BETAMETHASONE VALERATE USP(CRM STANDARD) BETAMETHASONE VALERATE WHO(CRM STANDARD)