(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid
![(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Structure](CAS/20150408/GIF/1335210-34-8.gif)
- CAS No.
- 1335210-34-8
- Chemical Name:
- (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid
- Synonyms
- BNKY001-DL02;(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahy...;(3S,7R)-11-Methoxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxylic acid;(4R,12aS)-3,4,6,8,12,12a- hexahydro -7- methoxy -4- methyl -6,8- dioxo -2H- pyrido [1',2':4,5] pyrazino [2,1-b] [1;(4R,12aS)-3,4,6,8,12,12a- hexahydro -7- methoxy -4- methyl -6,8- dioxo -2H- pyrido [1',2':4,5] pyrazino [2,1-b] [1;(4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxylic acid;(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid;(4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2Hpyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid;(4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid;(4R,12aS)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
- CBNumber:
- CB12729256
- Molecular Formula:
- C14H16N2O6
- Molecular Weight:
- 308.29
- MOL File:
- 1335210-34-8.mol
- Modify Date:
- 2024/3/15 11:13:09
(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Chemical Properties,Uses,Production
Synthesis
5-methoxy-6-(methoxycarbonyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-3-carboxylic acid (3.38 g, 107.24 mmol) was dissolved in 33 ml of acetonitrile. Add glacial acetic acid (3 ml) and methanesulfonic acid (0.21 ml, 3.24 mmol) in a 150 ml round bottom flask at room temperature. The reaction was heated to 60 ° C for 19 h. (R)-3-Amino-1-butanol (1.44 ml, 1.34 g, dissolved in 2.25 ml of CH3CN) was slowly added dropwise to the above reaction solution. The reaction was continued to stir at 60 ° C for 18 h to give a white suspension. The reaction solution was concentrated to dryness under reduced pressure to give a concentrate. Add 25 ml of CH2Cl2 and 1N HCl (25 ml). The organic layer was separated, and the aqueous layer was extracted with CH 2 Cl 2 (25 ml x 2). The organic layers were combined and concentrated to dryness under reduced pressure to give crude 6 2.2g. The crude product was recrystallized from 15 ml of MeOH/petroleum ether = 6/1 solvent. After filtration and drying, a pale yellow solid product of (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid was obtained, 1.72 g.
(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Suppliers
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1335210-34-8((4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid)Related Search:
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