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5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Structure
CAS No.
173140-90-4
Chemical Name:
5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone
Synonyms
(R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one;BNKY004-IM01;8-benzoxy-5-(R)-oxiranyl-1H-quinolin-2-one;5-(2R) -2-epoxyl-8-benzoxy-2 (1H) -quinolone;5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone;(R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone;2 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone;8-(Benzyloxy)-5-[(2R)-oxiran-2-yl]quinolin-2(1H)-one;2(1H)-Quinolinone, 5-(2R)-oxiranyl-8-(phenylmethoxy)-;5-(2R)-2-Oxiranyl-8-(phenylmethoxy)-2(1H)-quinolinone
CBNumber:
CB72516579
Molecular Formula:
C18H15NO3
Molecular Weight:
293.32
MOL File:
173140-90-4.mol
Modify Date:
2023/11/6 16:47:05

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Properties

Melting point 155 - 157°C
Boiling point 556.0±50.0 °C(Predicted)
Density 1.298
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 10.92±0.70(Predicted)
form Solid
color White to Pale Yellow
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Chemical Properties,Uses,Production

Uses

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Synthesis_173140-90-4
A 5 liter flask equipped with a mechanical stirrer, thermometer, and refluxing condenser was charged with 8-benzyloxy-5-[(R)-(2-bromo-1-hydroxyethyl)]-carbostyriI (70gms/0.187 moles), potassium carbonate (74 gmsl 0.536 moles), acetone (3.5 liters) and water (35 ml). The resulting slurry 'was heated to reflux and maintained for 2% hours. After completion of reaction, the hot mass was filtered on hylo bed to remove inorganics. The residue was slurried in dichloromethane (200 ml) and filtered on hyflo bed. The filtrates were combined together and concentrated under vacuum completely. The residue was dissolved. in dichloromethane (500ml) and filtered on hyflo bed to remove traces of insolubles and washed with dichloromethane(100 ml). The clear filtrate was distilled completely to obtain residue. The residue was charged with methanol (70 ml), stirred and heated to 50??C for 30 minutes. The slurry obtained was cooled to 25-30??C,chilled to 0- 5??C, stirred for 1 hour. The resulting solid was isolated by filtration, washed with methanol (30ml), followed by diisopropylether (100ml) and dried under vacuum at 60-65 ??C for 10-12 hours to yield 40-41 gms of 8-benzyloxy- 5-(R)-oxiranylcarbostyril.

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 179)Suppliers
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Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
BIONNA MEDICINE CO.,LTD 01056380788-8515; +8618518759099 China 52 58 Inquiry
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ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29897 58 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2141 58 Inquiry
2(1H)-Quinolinone, 5-(2R)-oxiranyl-8-(phenylmethoxy)- 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone Indacaterol interMediate :2 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 8-(Benzyloxy)-5-[(2R)-oxiran-2-yl]quinolin-2(1H)-one 2 5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone 8-benzoxy-5-(R)-oxiranyl-1H-quinolin-2-one (R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone BNKY004-IM01 5-[(2R)-oxiran-2-yl]-8-phenylmethoxy-1H-quinolin-2-one 2(1H)-Quinolinone, 5-(2R)-2-oxiranyl-8-(phenylmethoxy)- 8-(benzyloxy)-5-((1R)-2-((5-ethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)quinolin-2(1H)-one fumarate (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one( Indacaterol Impurity 5) (R)-8-(Benzyloxy)-5-(oxiran-2-yl)quinolin-2(1H)-one 5-(2R)-2-Oxiranyl-8-(phenylmethoxy)-2(1H)-quinolinone 5- (2R) -2-epoxyethanyl-8-benzyloxy-2 (1H) - quinolone 5-(2R) -2-epoxyl-8-benzoxy-2 (1H) -quinolone 173140-90-4