Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >API >Circulatory system drugs >Antihypertensive drugs >5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Structure
CAS No.
124750-51-2
Chemical Name:
5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
Synonyms
Losaint-B;ALSTint-A04;Valsartan IMP;Valsartan Impurity;Valsartan Impurity 8;Valsartan Impurity 9;TRITYLATED BROMO IMP;Valsartan impurity 19;Fimasartan Impurity B;Valsartan intermediate
CBNumber:
CB8369024
Molecular Formula:
C33H25BrN4
Molecular Weight:
557.48
MOL File:
124750-51-2.mol
Modify Date:
2024/7/29 15:17:36
Request For Quotation

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Properties

Melting point 152-155°C
Boiling point 61°C/12mmHg(lit.)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility Soluble in Chloroform and Methanol (Sparingly)
form Solid
pka 0.29±0.10(Predicted)
color White
Stability Moisture Sensitive
InChI InChI=1S/C33H25BrN4/c34-24-25-20-22-26(23-21-25)30-18-10-11-19-31(30)32-35-36-37-38(32)33(27-12-4-1-5-13-27,28-14-6-2-7-15-28)29-16-8-3-9-17-29/h1-23H,24H2
InChIKey ZTFVTXDWDFIQEU-UHFFFAOYSA-N
SMILES N1(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C(C2=CC=CC=C2C2=CC=C(CBr)C=C2)=NN=N1
CAS DataBase Reference 124750-51-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H315-H319-H228
Precautionary statements  P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
RIDADR  UN 2811 6.1/PG III
HazardClass  6.1
PackingGroup  III

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Chemical Properties,Uses,Production

Description

5-[4′-Bromomethyl-(1,1′-biphenyl)-2-yl]-1-triphenylmethyltetrazole is an intermediate in the synthesis of Losartan and Valsartan. Utilized for various purposes, 5-[4′-Bromomethyl-(1,1′-biphenyl)-2-yl]-1-triphenylmethyltetrazole has found application as a fluorescent probe to identify DNA damage. It serves as a photosensitizer in photodynamic therapy and acts as a catalyst in polymer synthesis. Furthermore, this compound functions as a fluorescent label to detect proteins and as a fluorescent indicator to detect metal ions.

Chemical Properties

Off-White Solid

Uses

Used as Olmesartan medoxomil related intermediate, Olmesartan medoxomil is an angiotensin II receptor antagonist[1]. 

Application

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole is an important pharmaceutical intermediate. It can be used in the preparation of olmesartan medoxomil key intermediates, Losartan potassium, Valsartan, Candesartan and molecular sieve catalysts.

Hazard

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole has an acute toxin and is irritating to skin and eyes.

References

[1] HAI Z. Determination of the related substances in N-triphenylmethyl-5-(4’-bromomethylbiphenyl-2-yl-) terazole by HPLC[J]. West China Journal of Pharmaceutical Sciences, 2015.

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Preparation Products And Raw materials

Raw materials

Preparation Products

Trityl olmesartan Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester 1H-Imidazole-4,5-dicarbonitrile, 2-butyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]- diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate
2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
chevron_left

1of2

chevron_right

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Suppliers

Global( 545)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
VASISTA LIFE SCIENCES PRIVATE LIMITED +91-04029554774 +91-9010855544 Hyderabad, India 153 58 Inquiry
Saptagir Laboratories PVT.LTD. +91-9059978049 +91-9059978049 Telangana, India 31 58 Inquiry
SGMR PHARMACEUTICALS PVT LTD +91-9032001889 +91-9032001889 Telangana, India 83 58 Inquiry
Credas Labs Pvt Ltd +91 9133918031 Hyderabad, India 119 58 Inquiry
Aurona Med Pharma Private Limited +91-9618434204 +91-8074941863 Hyderabad, India 24 58 Inquiry
SEUTIC +91-8309787199 +91-8309787199 Hyderabad, India 124 58 Inquiry
Arown Pharma +91-914040277600 +91-8309108338 Hyderabad, India 46 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
Cefa-Cilinas Biotics Pvt Ltd +91-7875033155 +91-8080701561 Maharashtra, India 121 58 Inquiry
Supplier Advantage
GLR Innovations 58
VASISTA LIFE SCIENCES PRIVATE LIMITED 58
Saptagir Laboratories PVT.LTD. 58
SGMR PHARMACEUTICALS PVT LTD 58
Credas Labs Pvt Ltd 58
Aurona Med Pharma Private Limited 58
SEUTIC 58
Arown Pharma 58
VGS SYNTHESIS PRIVATE LIMITED 58
Cefa-Cilinas Biotics Pvt Ltd 58

Related articles

124750-51-2(5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole)Related Search:

4,4'-Dimethylbiphenyl Decabromodiphenyl oxide FIREMASTER BP-6 Biphenyl 2-Bromobiphenyl
2,3,5-Triphenyltetrazolium chloride 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-4-Methyl-6-oxo-1,6-dihydropyriMidin-5-yl) -N,N-diMethylacetaMide Fimasartan 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide 2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide
OlMesartan MedoxoMil iMpurity V N-Trityl Olmesartan Ethyl Ester METHYL TRIPHENYLMETHYL ETHER 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester
Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity 4,5-Dimethyl-1,3-dioxol-2-one
chevron_left

1of4

chevron_right
N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole N-(TRIPHENYLMETHYL)-5-(4'-BROMOMETHYLBIPHENYL-2-YL) TETRAZOLE 5-(4'-BROMOMETHYL-1,1'-BIPHENYL-2-YL)-1-TRIPHENYLMETHYL-1H-TETRAZOLE 5-(4'-BROMOMETHYL-BIPHENYL-2-YL)-1-TRITYL-1H-TETRAZOLE 1H-Tetrazole, 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)- Trityl tetrazole bromomethyl biphenyl 5-(4'-(BROMOMETHYL)(1,1'-BIPHENYL)-2-YL)-1-TRITYL- 5-[4'-(Bromomethyl)[1,1'-Biphenyl]-1-(Triphenylmethyl)Tetrazole] 2-(N-Triphenylmethyltetrazolyl)-4-Bromomethylbiphenyl)97% Valsartan intermediate 5-[4Bromomethyl-(1,1biphenyl)-2-yl]-1-triphenylmethyltetrazole N-(TRIPHENYLMETHYL)-5-(4''-BROMOMETHYLBIPHENYL-2-YL-)TETRAZOLE(BBTT) 5-[4'-bromomethyl-1,1'-biphenyl-2-yl]-1-trityl-1H-tetrazole (TRIPHENYLMETHYL)TETRAZOLE 5-(4'-(BROMOMETHYL)(1,1'-BIPHENYL)-2-YL)-1-TRITYL-1H-TETRAAZOLE N-(Triphenylmethyl)-5-(4’-bromomethylbiphenyl-2-yi-)tetrazole N-(Triphenylmethyl)C5-(4'-Bromomethylbiphenyl-2Yl)Tetrazole n-(triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole,N-(Triphenyl methyl)-5-(4'-Bromomethyl-biphenyl-2-yl)tetrazole(TTBB,BBTT) 5-(4'-BroMoMethyl-1,1'-biphenyl-2-yl)-1-triphenylM 5-[5-(broMoMethyl)-2-phenylphenyl]-1-(triphenylMethyl)-1H-1,2,3,4-tetrazole Candesartan BroMo IMpurity：5-(4'-(BroMoMethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetrazole [2'-(1-Trityl-1H-tetrazol-5-yl)biphenyl-4-yl]Methyl BroMide 4-[2'-(N-TriphenylMethyltetrazol-5-yl)phenyl]benzyl BroMide 4'-BroMoMethyl-2-(1-trityl-1H-tetrazol-5-yl)biphenyl 4-BroMoMethyl-2'-[N-triphenylMethyl-1H-tetrazol-5-yl]biphenyl N-(Trityl)-5-(4'-BroMoMethyl Biphenyl-2-Yl)-Tetrazole Irbesartan BroMo IMpurity Losartan BroMo N1 Trityl IMpurity Valsartan BroMo IMpurity Irbesartan BroMo N1-Trityl IMpurity 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole OlMesartan IMpurity (N-(TriphenylMethyl)-5-(4'-broMoMethylbiphenylyl)tetrazole) 5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetrazole 200mg Desbutoxy Valsartan Benzyl Ester Candesartan Bromo N1-Trityl Impurity Valsartan Impurity N-(Tm)-5-(4'-bromomethylbiphenyl-2-yl ) tetrazole(TTBB) Valsartan Impurity 8 Valsartan Impurity 9 (R)-2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)propionamido)-3-methylbutanoic acid Valsartan IMP Valsartan impurity 19 5-[4'-(Bromomethyl)-1,1'-biphenyl-2-yl]-1-triphenylmethyl-1H-tetrazole> Irbesartan Bromo N2-Trityl Impurity 5-(4'-Bromomethyl-1,1'- biphenyl-2-yl)-1- triphenylmethyl-1Htetrazole （BBTT） 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole USP/EP/BP 1-Triphenylmethyl-5-[4'-(bromomethyl)biphenyl-2-yl]tetrazole DISCONTINUED, offer B685310 N-(Triphenylmethyl)-5-(4’bromomethyl-biphenyl-2- yl)tetrzole(TTBB) 5-(4'-Bromomethyl-1,1'biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole (TTB) 1-Triphenylmethyl-5-(4'-bromomethyl-1, 1'-biphenyl-2-yl)-1H-tetrazole N-(Triphenylmethyl)-5-(4'romomethyl)biphenyl-2-yl)tetrazole N-TRIPHENYLMETHYL)-5-(4-BROMOMETHYLBIPHENYL-2-YL-)TETRAZOLE (TTBB) N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole (TTBB) Losartan Bromo N1 Trityl Impurity/ Olmesartan Impurity N-(Triphenylmethyl)-5-(4’-bromomethylbiphenyl-2-yl)tetrazole Olmesartan Impurity N-(Triphenylmethyl)-5-(4’-bromomethylbiphenyl-2-yl)tetrazole/ Losartan Bromo N1 Trityl Impurity Azilsartan medoxomil impurity227 candesartan cilexetil impurity1357 Candesartan Bromo N1-Trityl ImpurityQ: What is Candesartan Bromo N1-Trityl Impurity Q: What is the CAS Number of Candesartan Bromo N1-Trityl Impurity Q: What is the storage condition of Candesartan Bromo N1-Trityl Impurity Q: What are the applications of Candesartan Bromo N1-Trityl Impurity Fimasartan Impurity B