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Fimasartan

Fimasartan Structure
CAS No.
247257-48-3
Chemical Name:
Fimasartan
Synonyms
Kanarb;BR-A-657;Fimasartan;Fimasartan D4;Unii-p58222188p;KANARB; BR-A-657;Fimasartan(BR-A-657);FiMasartan USP/EP/BP;Fimasartan Impurity H;2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim
CBNumber:
CB22128722
Molecular Formula:
C27H31N7OS
Molecular Weight:
501.65
MOL File:
247257-48-3.mol
MSDS File:
SDS
Modify Date:
2024/4/25 13:42:50
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Fimasartan Properties

Melting point >155°C (dec.)
Boiling point 693.0±65.0 °C(Predicted)
Density 1.25
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 4.16±0.10(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

Fimasartan price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML3256 Fimasartan ≥98% (HPLC) 247257-48-3 10MG ₹8258.4 2022-06-14 Buy
Sigma-Aldrich(India) SML3256 Fimasartan ≥98% (HPLC) 247257-48-3 50MG ₹33322.2 2022-06-14 Buy
Product number Packaging Price Buy
SML3256 10MG ₹8258.4 Buy
SML3256 50MG ₹33322.2 Buy

Fimasartan Chemical Properties,Uses,Production

Description

Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the brand name Kanarb by Boryung Pharmaceuticals.

Uses

Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.

Biological Activity

Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

Mechanism of action

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.

Fimasartan Preparation Products And Raw materials

Raw materials

2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide

Preparation Products

Fimasartan Suppliers

Global( 179)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SURYA LIFE SCIENCES LIMITED +91-2646226290 +91-9428511112 Gujarat, India 62 58 Inquiry
GMFC LABS PVT LTD +91-9133370278 +91-9133370278 Hyderabad, India 44 58 Inquiry
Zydus Lifesciences Ltd. +91-0265-2315243 +91-6358895661 Gujarat, India 89 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Triveni Interchem Private Limited (Group Of Triveni... 08046042087 Gujarat, India 497 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Zhuhai Hairuide Bioscience and Technology Co., Ltd +8618928027945 China 97 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12459 58 Inquiry
Supplier Advantage
SURYA LIFE SCIENCES LIMITED 58
GMFC LABS PVT LTD 58
Zydus Lifesciences Ltd. 58
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Triveni Interchem Private Limited (Group Of Triveni... 58
Pharma Affiliates 58
Zhuhai Hairuide Bioscience and Technology Co., Ltd 58
Hebei Mojin Biotechnology Co., Ltd 58

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2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one Fimasartan Unii-p58222188p 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide 2-(2-butyl-4-Methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methoxy)pyriMidin-5-yl)-N,N-diMethylacetaMide-yl)-N,N-diMethylacetaMide BR-A-657 Kanarb 5-PyriMidineethanethioaMide,2-butyl-1,6-dihydro-N,N,4-triMethyl-6-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]- Fimasartan(BR-A-657) 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide Fimasartan Impurity H KANARB; BR-A-657 2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide 2-(2-butyl-4-methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[ 1,1'-biphenyl]-4-yl)methoxy)pyrimidin-5-yl)-N,N- dimethylacetamide FiMasartan USP/EP/BP 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one USP/EP/BP 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)- 4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)- N,N-dimethylethanethioamide Fimasartan D4 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl] methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (Fimasartan) 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide 247257-48-3 C27H31N7OS Inhibitors API