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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >Adrenergic Receptor agonists >Indacaterol

Indacaterol

Indacaterol Structure
CAS No.
312753-06-3
Chemical Name:
Indacaterol
Synonyms
CS-272;Arcapta;Indaterol;Indacaterol;Indacaterol-d3;Indacaterol (Onbrez;Indacaterol USP/EP/BP;Indacaterol acetate salt;Indacaterol and its intermediates;Procaterol Impurity 17 ammonium salt
CBNumber:
CB82512068
Molecular Formula:
C24H28N2O3
Molecular Weight:
392.49
MOL File:
312753-06-3.mol
MSDS File:
SDS
Modify Date:
2023/11/7 17:33:14
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Indacaterol Properties

Melting point >165°C (dec.)
Boiling point 660.3±55.0 °C(Predicted)
Density 1.27
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 8.68±0.20(Predicted)
form Solid
color Off-White to Light Yellow
InChIKey QZZUEBNBZAPZLX-QFIPXVFZSA-N
SMILES N1C2=C(C([C@@H](O)CNC3CC4=C(C3)C=C(CC)C(CC)=C4)=CC=C2O)C=CC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H315-H312-H332-H302-H335
Precautionary statements  P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
3 0

Indacaterol Chemical Properties,Uses,Production

Description

Inhaled β2 adrenoceptor agonists are effective in the management of asthma and COPD, primarily through their bronchodilating properties. These drugs induce bronchodilation by causing direct relaxation of airway smooth muscle through activation of adenylate cyclase, which in turn increases intracellular cAMP levels. Indacaterol is the newest β2 agonist to reach the market. It is an ultra-long-acting agent with a duration of action suitable for once-a-day dosing. Indacaterol is supplied as an aerosol formulation of its maleate salt and is administered via a dry powder inhaler device. It is specifically approved for once-daily maintenance treatment of airflow obstruction in adult patients with COPD. In preclinical models, indacaterol is close to a full agonist at the human b2 adrenoceptor (Emax = 73 ± 1% of isoprenaline′s maximal effect, pEC50 = 8.06 ±0.02) while salmeterol displays only partial efficacy (38 ±1%). The functional selectivity profile of indacaterol over β1 human adrenoceptors is similar to that of formoterol, whereas its β3 adrenoceptor selectivity profile is similar to that of formoterol and salbutamol.

Uses

Indacaterol is a β-adrenoreceptor agonists for treatment of asthma and bronchodilator treatment for patients with chronic obstructive pulmonary diseases.

Definition

ChEBI: A monohydroxyquinoline that consists of 5-[(1R)-2-amino-1-hydroxyethyl]-8-hydroxyquinolin-2-one having a 5,6-diethylindan-2-yl group attached to the amino function. Used as the maleate salt for treatment of chronic obstructive pulmonary di ease.

Side effects

The most commonly reported adverse events associated with indacaterol treatment were nasopharyngitis, upper respiratory tract infection, and headache and cough following inhalation. Adverse events were mild or moderate in most cases, and became less frequent with continued treatment.

Indacaterol Preparation Products And Raw materials

Raw materials

753498-33-8 8-Benzyloxy-5-(2-bromoacetyl)-2-hydroxyquinoline N-benzyl-5,6-diethyl-2,3-dihydro-1H-inden-2-amine 5-(2,2-dihydroxyacetyl)-8-phenylmethoxy-1H-quinolin-2-one 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone
2-Amino-(5,6-diethyl)-indane
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Preparation Products

Indacaterol Suppliers

Global( 173)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
BDR Pharmaceuticals International Pvt Ltd +91-2240560560 +91-7718884418 Maharashtra, India 206 58 Inquiry
Maithri Drugs Pvt Ltd +91-9059204566 +91-9848881740 Telangana, India 64 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Jinan Million Pharmaceutical Co., Ltd 0531-68659554 +8613031714605 China 192 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10978 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21669 55 Inquiry
Supplier Advantage
J S LABS 58
Ralington Pharma 58
BDR Pharmaceuticals International Pvt Ltd 58
Maithri Drugs Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
AFINE CHEMICALS LIMITED 58
Jinan Million Pharmaceutical Co., Ltd 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55

Indacaterol Spectrum

Indacaterol(312753-06-3)1HNMR

312753-06-3(Indacaterol)Related Search:

(S)-Indacaterol 2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide Indacaterol Impurity 7 METHYL TRIPHENYLMETHYL ETHER
2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-4-Methyl-6-oxo-1,6-dihydropyriMidin-5-yl) -N,N-diMethylacetaMide Indacaterol interMediate Triphenylmethanol 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Fimasartan
Indacaterol Impurity 12 Indacaterol IMrity Indacaterol Maleate BECLOMETHASONE (r)-budesonide
Aclidinium bromide Salmeterol Glycopyrrolate
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Indacaterol 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one (R)-5-(2-(5,6-diethyl-2,3-dihydro-1H-inden-2-ylaMino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, Maleate salt Arcapta 5-[2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylaMino)-(1R)-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one (R)-5-(2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)- 2(1H)-Quinolinone,5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy- Indacaterol-d3 CS-272 Indacaterol and its intermediates Indacaterol USP/EP/BP Indacaterol acetate salt 5-[2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-(1R)-hydro... IndacaterolQ: What is Indacaterol Q: What is the CAS Number of Indacaterol Q: What is the storage condition of Indacaterol Q: What are the applications of Indacaterol asthma,Beta Receptor,HT1080 cells,myocardial infarction,Adrenergic Receptor,NF-κB,β-arrestin2,Indacaterol,Inhibitor,COPD,inhibit,heart failure Indacaterol /5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one Procaterol Impurity 17 ammonium salt Indaterol Indacaterol (Onbrez (R) -5-[2- (5, 6-diethyldihydroindene-2-amino) -1-hydroxyethyl] -8-hydroxy-1H-quinolin-2-one 312753-06-3 Intermediates & Fine Chemicals Pharmaceuticals Inhibitors Agonist Amines Aromatics Heterocycles