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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Microbiology >Integrase Inhibitors >GSK1349572

GSK1349572

GSK1349572 Structure
CAS No.
1051375-16-6
Chemical Name:
GSK1349572
Synonyms
Dolutegravir;Dolutegravi;S/GSK1349572;Dulutegravir;Dolutegravir (GSK1349572);CS-9;134413;S-349572;GSK1349572;BNKY001-DL04
CBNumber:
CB62538916
Molecular Formula:
C20H19F2N3O5
Molecular Weight:
419.38
MOL File:
1051375-16-6.mol
MSDS File:
SDS
Modify Date:
2024/1/4 13:52:25
Request For Quotation

GSK1349572 Properties

Melting point 187-189°C
Boiling point 669.0±55.0 °C(Predicted)
Density 1.53
storage temp. Refrigerator
solubility DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
pka 4.50±1.00(Predicted)
form Solid
color White to Pale Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

GSK1349572 Chemical Properties,Uses,Production

Description

In August 2013, the US FDA approved dolutegravir (also referred to as S/GSK1349572) for the treatment of HIV-1 infection in adults and children ages 12 years and older in combination with other antiretroviral drugs. Dolutegravir was approved in Canada in November 2013. HIV/AIDS remains a global epidemic with 35 million people infected, including 2.3 million new infections as of 2012. Dolutegravir joins raltegravir and elvitegravir (this chapter of ARMC) as the latest of three FDA-approved HIV integrase strand transfer inhibitors (INSTIs). Dolutegravir was discovered by rational design from a literature diketo acid HIV integrase inhibitor utilizing X-ray coordinates to predict ideal bond angles between the diketone and distal benzyl group. In dolutegravir, the monocyclic component of the reported inhibitor was replaced with the tricyclic carbamoyl pyridone moiety. The researchers postulated that the appropriate arrangement of three oxygens would permit chelation with two magnesium ions in the binding site thus affording improved potency. Ultimately, this arrangement along with further modifications afforded dolutegravir, a potent inhibitor of HIV integrase (IC50=1.7 nM).

Chemical Properties

White Solid

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]ox zine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.

GSK1349572 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK1349572 Suppliers

Global( 342)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
Aurobindo Pharma Limited +914066725000 Telangana, India 112 58 Inquiry
Lupin Ltd +91-8019896181 +91-8019896181 Maharashtra, India 93 58 Inquiry
Macleods Pharmaceuticals Limited +91-2266762800 +91-2266762800 Maharashtra, India 116 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Anlon Healthcare Pvt Ltd +91-2812562538 +91-7069690081 Gujarat, India 54 58 Inquiry
Venkatasai Life Sciences +91-9908134868 +91-8008303069 Hyderabad, India 186 58 Inquiry
Solara Active Pharma Sciences Ltd +91-8046632100 +91-7075706520 Bangalore, India 65 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
ShreeGen Pharma Ltd (part of Rumit Group of Companies) +91-4023869399 +91-9664830616 Telangana, India 25 58 Inquiry
Supplier Advantage
J S LABS 58
Aurobindo Pharma Limited 58
Lupin Ltd 58
Macleods Pharmaceuticals Limited 58
HRV Global Life Sciences 58
Anlon Healthcare Pvt Ltd 58
Venkatasai Life Sciences 58
Solara Active Pharma Sciences Ltd 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
ShreeGen Pharma Ltd (part of Rumit Group of Companies) 58

GSK1349572 Spectrum

GSK1349572(1051375-16-6)1HNMR

1051375-16-6(GSK1349572)Related Search:

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Glatiramer acetate Dolutegravir sodium 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile BMS707035 Raltegravir
MK-2048 Ibrutinib Elvitegravir
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Dolutegravir API 2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)- (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Dolutegravir (GSK1349572) GSK1349572, S-349572, GSK572 (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Dolutegravir, >=98% Dolutegravir free acid GSK1349572 (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide S/GSK1349572 (GSK1349572) GSK1349572(dolutegravir) dolutegravir/GSK1349572/S-349572 Dolutegravir (S/GSK1349572 CS-9 Dolutegravir - GSK 1349572 | Soltegravir | Tivicay BNKY001-DL04 S/GSK1349572 (Dolutegravir) 134413 Dolutegravir DTG (3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide Pharmaceutical ingredient against HIV GSK1349572 GSK1349572 USP/EP/BP Dolutegravir (0.1 mg/mL in Methanol) Dolutegravir D3Q: What is Dolutegravir D3 Q: What is the CAS Number of Dolutegravir D3 Q: What is the storage condition of Dolutegravir D3 Q: What are the applications of Dolutegravir D3 DolutegravirQ: What is Dolutegravir Q: What is the CAS Number of Dolutegravir Q: What is the storage condition of Dolutegravir Q: What are the applications of Dolutegravir Dolutegravir Tablet Dolutegravir (GSK1349572) Dolutegravi Dolutegravir S/GSK1349572 Dulutegravir The degree of root wei Dolutegravir,HIV Integrase,HIV,inhibit,Human immunodeficiency virus,Inhibitor (4R, 12aS) - N - [(2,4-difluorophenyl) methyl] -3,4,6,8,12,12a - hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyridino [1 ', 2': 4,5] pyrazino [2,1-b] [1,3] oxazin-9-formamide Dolutegravir Impurity L Dolutegravir Impurity 40 S-349572 Dotiravir Impurity 1 (4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide 1051375-16-6 10513375-16-6 134678-17-8 C20H19F2N3O5 API Inhibitors HIV-1 integrase inhibitor Inhibitor CMLLYL 1051375-16-6