4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
![4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Structure](CAS/GIF/500287-72-9.gif)
- CAS No.
- 500287-72-9
- Chemical Name:
- 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
- Synonyms
- Rilpivirine;Rilpivirin;(E)-4-(4-(4-(2-cyanovinyl)-2,6-diMethylphenylaMino)pyriMidin-2-ylaMino)benzonitrile;TMC 278;DB08864;Pivelin;R 278474;pivirine;Rilpivirine(RPV);Rilpivirine, >=98%
- CBNumber:
- CB81454833
- Molecular Formula:
- C22H18N6
- Molecular Weight:
- 366.42
- MOL File:
- 500287-72-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/26 17:21:34
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Properties
Melting point | 245℃ |
---|---|
Boiling point | 634.1±65.0 °C(Predicted) |
Density | 1.27 |
storage temp. | Refrigerator |
solubility | Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly) |
pka | 4.56±0.10(Predicted) |
form | Solid |
color | Yellow |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS07,GHS09 |
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Signal word | Warning | |||||||||
Hazard statements | H319-H400-H302-H410 | |||||||||
Precautionary statements | P273-P391-P501-P264-P270-P301+P312-P330-P501-P273-P391-P501-P264-P280-P305+P351+P338-P337+P313P | |||||||||
NFPA 704 |
|
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Chemical Properties,Uses,Production
Description
In May 2011, the U.S. FDA approved rilpivirine in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) 1 infection in treatment-naive adult patients. Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV agents. It is highly potent against a range of wild-type HIV strains (EC50=0.07–1.0 nM),~10–20 timesmore potent than the NNRTI efavirenz (Sustiva), and active against HIV strains resistant to other NNRTIs. The discovery of rilpivirine was guided by molecular modeling and X-ray crystallography of HIV-1 RT complexed with inhibitors. The synthesis of rilpivirine is accomplished by an efficient 6-step route in which the key step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.
Chemical Properties
N/ABright Yellow Solid
Definition
ChEBI: An aminopyrimidine that is pyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 4-cyanophenyl and 4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl groups respectively. Used for treatment of HIV.
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
SynThink RESEARCH CHEMICALS | +91-8177860948 +91-8177860948 | Mumbai, India | 494 | 58 | Inquiry |
Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Chiral Biosciences Limited | 09441920381 | Mallapur, India | 41 | 58 | Inquiry |
Angel Bio Pharma | 08069013898Ext 347 | Ahmedabad, India | 50 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
Supplier | Advantage |
---|---|
J S LABS | 58 |
SynThink RESEARCH CHEMICALS | 58 |
Varanous Labs Pvt Ltd | 58 |
A.J Chemicals | 58 |
CLEARSYNTH LABS LTD. | 58 |
Chiral Biosciences Limited | 58 |
Angel Bio Pharma | 58 |
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
Hebei Yanxi Chemical Co., Ltd. | 58 |
Capot Chemical Co.,Ltd. | 60 |
500287-72-9(4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile)Related Search:
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