ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Microbiology >Reverse Transcriptase Inhibitors >4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

CAS No.: 500287-72-9

Chemical Name:: 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

Synonyms: Rilpivirine;Rilpivirin;(E)-4-(4-(4-(2-cyanovinyl)-2,6-diMethylphenylaMino)pyriMidin-2-ylaMino)benzonitrile;TMC 278;DB08864;Pivelin;R 278474;pivirine;Rilpivirine(RPV);Rilpivirine, >=98%

CBNumber:: CB81454833

Molecular Formula:: C22H18N6

Molecular Weight:: 366.42

MOL File:: 500287-72-9.mol

MSDS File:: SDS

Modify Date:: 2024/4/26 17:21:34

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4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Properties

Melting point	245℃
Boiling point	634.1±65.0 °C(Predicted)
Density	1.27
storage temp.	Refrigerator
solubility	Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly)
pka	4.56±0.10(Predicted)
form	Solid
color	Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H319-H400-H302-H410

Precautionary statements

P273-P391-P501-P264-P270-P301+P312-P330-P501-P273-P391-P501-P264-P280-P305+P351+P338-P337+P313P

NFPA 704

	0
2		0

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Chemical Properties,Uses,Production

Description

In May 2011, the U.S. FDA approved rilpivirine in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) 1 infection in treatment-naive adult patients. Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV agents. It is highly potent against a range of wild-type HIV strains (EC50=0.07–1.0 nM),～10–20 timesmore potent than the NNRTI efavirenz (Sustiva), and active against HIV strains resistant to other NNRTIs. The discovery of rilpivirine was guided by molecular modeling and X-ray crystallography of HIV-1 RT complexed with inhibitors. The synthesis of rilpivirine is accomplished by an efficient 6-step route in which the key step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.

Chemical Properties

N/ABright Yellow Solid

Definition

ChEBI: An aminopyrimidine that is pyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 4-cyanophenyl and 4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl groups respectively. Used for treatment of HIV.

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Suppliers

Global( 246)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
J S LABS	+91-7330612784 +91-7330612784	Tamil Nadu, India	160	58	Inquiry
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Supplier	Advantage
J S LABS	58
SynThink RESEARCH CHEMICALS	58
Varanous Labs Pvt Ltd	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Chiral Biosciences Limited	58
Angel Bio Pharma	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Spectrum

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile(500287-72-9)¹HNMR

500287-72-9(4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile)Related Search:

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4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile 4-[[4-[[4-[(E)-2-Cyanovinyl]-2,6-diMethylphenyl]aMino]pyriMidin-2-yl]aMino]benzonitrile 4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-diMethylphenyl}aMino)pyriMidin-2-yl]aMino}benzonitrile Rilpivirine(R 278474 Rilpivirine (R 278474, TMC 278) 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile R 278474 TMC 278 Benzonitrile,4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-diMethylphenyl]aMino]-2-pyriMidinyl]aMino]- 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile Rilpivirine R 278474 Rilpivirine, >=98% R 278474; TMC 278; R-278474; R278474; TMC278; TMC-278 DB08864 pivirine BENZONITRILE。RILPIVIRINE 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile USP/EP/BP 4-[4-[4-[(E)-2-Cyanovinyl]-2,6-dimethylphenylamino]pyrimidin... RilpivirineQ: What is Rilpivirine Q: What is the CAS Number of Rilpivirine Q: What is the storage condition of Rilpivirine Q: What are the applications of Rilpivirine (E)-4-(4-(4-(2-cyanovinyl)-2,6-diMethylphenylaMino)pyriMidin-2-ylaMino)benzonitrile Rilpivirine Rilpivirin Pivelin Rilpivirine/TMC-278 Rilpivirine(RPV) Glycerol Impurity 39 500287-72-9 C22H18N6 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals