ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Antiviral drugs >Tenofovir disoproxil

Tenofovir disoproxil

CAS No.: 201341-05-1

Chemical Name:: Tenofovir disoproxil

Synonyms: SRY;Tdf;CS-589;GS 4331;Aids080741;Aids-080741;Bis(poc)pmpa;Pmpa prodrug;enofovirdisoproxil;Tenofov ir Disoprox

CBNumber:: CB0949152

Molecular Formula:: C19H30N5O10P

Molecular Weight:: 519.44

MOL File:: 201341-05-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:54:58

Request For Quotation

Tenofovir disoproxil Properties

Boiling point	642.7±65.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: ≥ 38 mg/mL (73.16 mM)
pka	4.20±0.10(Predicted)
form	Solid
color	White to off-white
CAS DataBase Reference	201341-05-1

Tenofovir disoproxil Chemical Properties,Uses,Production

Description

Tenofovir disoproxil is a prodrug in a manner similar to that of adefovir dipivoxil. In both cases, the phosphate esters are removed through the action of plasma esterase, leading in this case to tenofovir, which differs from adefovir by the presence of the indicated methyl group. Tenofovir disoproxil exhibits good bioavailability (25%), which is improved in the presence of food (35%). The drug is approved for the treatment of HIV infections in adult patients. Tenofovir diphosphate is an HIV RT inhibitor. The active form of tenofovir is the tenofovir diphosphate, which competes with dATP for incorporation into viral DNA, and when incorporated, tenofovir diphosphate results in premature termination of DNA growth and inhibition of DNA polymerase. Tenofovir disoproxil is indicated for treatment-experienced patients with HIV-1. The drug also appears to be effective in treatment-naive patients, but initial approval is for treatment-experienced patients. The drug is administered as one tablet taken once daily. It is recommended that the drug be combined with other RT inhibitors or HIV PIs, which results in additive or synergistic activity.

Uses

Tenofovir Disoproxil is a therapeutic option for nucleos(t)ide analog (NA)-experienced chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV). Also, it is an intermediate used in the synthesis of Tenofovir Disoproxil Dimer (T018515), which is a Tenofovir Disoproxil impurity.

Definition

ChEBI: An organic phosphonate that is the disoproxil ester of tenofovir. A prodrug for tenofovir, an HIV-1 reverse transcriptase inhibitor, tenofovir disoproxil is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.

General Description

Tenofovir disoproxil is a prodrug analogously with abacavir.Plasma and tissue esterases cleave the phosphateprotecting groups, releasing the active drug. The bioavailabilityof tenofovir is about 35% when administered withfood. The drug is approved by the Food and DrugAdministration (FDA) for the treatment of HIV infectionsin adult patients. Recommendations are for the drug to beadministered with other RT inhibitors or PIs to achievesynergism.

Tenofovir disoproxil Preparation Products And Raw materials

Raw materials

Preparation Products

Tenofovir disoproxil Suppliers

Global( 248)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
HRV Global Life Sciences	+91-9820219686 +91-9820219686	Telangana, India	379	58	Inquiry
Mangalam Drugs and Organics Ltd	+91-2222616300 +91-2222616200	Maharashtra, India	37	58	Inquiry
Darsh PharmaChem Pvt Ltd	+91-9712983850 +91-9712983850	Gujarat, India	33	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12459	58	Inquiry
Hebei Duling International Trade Co. LTD	+8617333973358	China	15438	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21676	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry

Supplier	Advantage
HRV Global Life Sciences	58
Mangalam Drugs and Organics Ltd	58
Darsh PharmaChem Pvt Ltd	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Duling International Trade Co. LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

Adverse effects of Tenofovir
Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to ....
Oct 16，2019

201341-05-1(Tenofovir disoproxil)Related Search:

Adenine p-Anisaldehyde Mycophenolate mofetil Tenofovir disoproxil fumarate Propyl butyrate

Tenofovir Propyl gallate Fluticasone propionate Methoxyacetic acid 4-Methoxybenzoic acid

Etretinate p-Anisidine (Trifluoromethoxy)benzene Malotilate POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE

Anisole Tenofovir alafenamide hemifumarate phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

chevron_left

1of4

chevron_right

(R)-(((((1-(6-AMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) diisopropyl dicarbonate (R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-bis(oxy))bis(methylene) diis 2,4,6,8-Tetraoxa-5-phosphanonanedioicacid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-,1,9-bis(1-Methylethyl) ester, 5-oxide TenofivirDisoproxilFumarate SRY Testis-determining factor Tenofovir disoproxil, >=98% Tenofovir disoproxil aspartate Tenofov ir Disoprox (R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-bis(oxy))bis(methylene) d 5-[[(1r)-2-(6-Amino-9h-Purin-9-Yl)-1-Methylethoxy]Methyl]-2,4,6,8-Tetraoxa-5-Phosphanononanedioic Acid Bis(1-Methylethyl) Ester 5-Oxide Tenofovir disoproxil 202138-50-9 (1:1 Fumarate salt) Aids080741 Aids-080741 Bis(isopropyloxymethylcarbonyl)pmpa Bis(poc)pmpa Gs 4331-05 (*1:1 fumarate salt*) Pmpa prodrug Tdf Tenofovirdisoproxil(Fumaratesalt) 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine Bis(isopropyloxycarbonyloxymethyl) ester tenofovir disoproxil price CS-589 TENOFOVIR DISOPROXIL (BIS(POC)-PMPA) TENOFOVIR DISOPROXIL (GS 4331) GS 4331 Tenofovir Disoproxil Base enofovirdisoproxil Tenofovir disoproxil USP/EP/BP Tenofovir DisoproxilQ: What is Tenofovir Disoproxil Q: What is the CAS Number of Tenofovir Disoproxil Q: What is the storage condition of Tenofovir Disoproxil Q: What are the applications of Tenofovir Disoproxil Tenofovir dipivoxil 201341-05-1 C19H32N5O10P