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phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate

phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate Structure
CAS No.
379270-35-6
Chemical Name:
phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
Synonyms
Monophenylester;TAF Impurity 3;GS7340 impurity1;GS7340 intermediate 1;Tenofovir Impurity 30;Tenofovir alafenamide-4;Tenofovir Alafenamide acid;Tenofovir Related Compound 2;Tenofovir Alafenamide Impurity 28;Tenofovir Alafenamide Impurity 18
CBNumber:
CB72729612
Molecular Formula:
C15H18N5O4P
Molecular Weight:
363.31
MOL File:
379270-35-6.mol
Modify Date:
2024/5/18 8:51:57

phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate Properties

Melting point 237-239°C
Boiling point 610.1±65.0 °C(Predicted)
Density 1.53±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated)
pka 2.09±0.10(Predicted)
form Solid
color White to Off-White

phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate Chemical Properties,Uses,Production

Application

[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]monophenylester is an antiviral agent and a Tenofovir intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor, used as an anti-HIV agent.

phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate Preparation Products And Raw materials

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[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, Monophenylester Tenofovir Related Compound 2 phenyl ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate GS7340 impurity1 GS7340 intermediate 1 phenylydrogen((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl) phosphonate phenyl hydrogen (R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate Phenyl hydrogen ({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonate Phosphonic acid,[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monophenylester Tenofovir alafenamide Intermediate Tenofovir alafenamide-4 [2-(6-Amino-purin-9- yl)-1-methyl-ethoxy methyl]-phosphonic acid monophenyl ester The intermediate of Tenofovir Alafenamide Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monophenyl ester (9CI) Tenofovir Impurity 30 Tenofovir alafenamide Intermediate 1 Tenofovir Alafenamide Impurity 28 TAF Impurity 3 Tenofovir Monophenyl Ester Impurity Phosphonic acid,[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methyleth... Monophenylester Tenofovir Alafenamide Impurity 18 (1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphinic acid 9-[(R)-2- (phenylphosphonomethoxy) propyl]adenine (PPMPA) Tenofovir Alafenamide Fumarate N-3 Tenofovir Alafenamide acid 379270-35-6 C15H18N5O4P Intermediate 379270-35-6