Tenofovir Alafenamide
- CAS No.
- 379270-37-8
- Chemical Name:
- Tenofovir Alafenamide
- Synonyms
- GS-7340;Alafenamide;phenyl hydrogen ((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate;Tenofovir Alafenamide Base;Tenofovir Alafenamide (GS-7340);(2R,3S)-2,3-bis(4-chlorophenyl)butane-2,3-diamine;CS-1724;GS-7340-03;GS-7340/GS7340;tenofovir alafenamide
- CBNumber:
- CB92627921
- Molecular Formula:
- C21H29N6O5P
- Molecular Weight:
- 476.47
- MOL File:
- 379270-37-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/7 13:17:53
| Melting point | >119°C (dec.) |
|---|---|
| Boiling point | 640.4±65.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 4.21±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChIKey | LDEKQSIMHVQZJK-QTJFZWIYNA-N |
| SMILES | C(OC(C)C)(=O)[C@H](C)NP(CO[C@H](C)CN1C2=C(N=C1)C(N)=NC=N2)(OC1=CC=CC=C1)=O |&1:6,12,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P321-P362+P364-P332+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Tenofovir Alafenamide Chemical Properties,Uses,Production
Description
Tenofovir alafenamide fumarate is an oral phosphonoamidate prodrug of the reverse transcriptase inhibitor tenofovir. It was approved by the USFDA for the treatment of chronic hepatitis B virus infection with compensated liver disease. Tenofovir alafenamide fumarate was discovered and developed by Gilead as a potentially safer form of the previously approved tenofovir disoproxil fumarate (Viread).
Uses
Tenofovir Alafenamide, also known as Tenofovir Impurity 51, is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B.
Definition
ChEBI: An L-alanine derivative that is isopropyl L-alaninate in which one of the amino hydrogens is replaced by an (S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)( henoxy)phosphoryl group. A prodrug for tenofovir, it is used (as the fumarate salt) in combination therapy for the treatment of HIV-1 infection.
Tenofovir Alafenamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 373)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Bulat Pharmaceutical Pvt Ltd | +91-8448085659 +91-8448085660 | Haryana, India | 123 | 58 | Inquiry |
| Lupin Ltd | +91-8019896181 +91-8019896181 | Maharashtra, India | 93 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Mangalam Drugs and Organics Ltd | +91-2222616300 +91-2222616200 | Maharashtra, India | 37 | 58 | Inquiry |
| Aspen Biopharma Labs Pvt Ltd | +91-9248058660 +91-9248058662 | Telangana, India | 234 | 58 | Inquiry |
| MSN LIFE SCIENCES PRIVATE LTD | +91 84523 34200 | New Delhi, India | 104 | 58 | Inquiry |
| ALEMBIC PHARMACEUTICALS LTD | +91 40 23704923 / 24 / 25 | New Delhi, India | 108 | 58 | Inquiry |
| MACLEODS PHARMACEUTICALS LTD | New Delhi, India | 106 | 58 | Inquiry | |
| EMCURE PHARMACEUTICALS LTD | +91 22 3061 0000 | New Delhi, India | 93 | 58 | Inquiry |
| AUROBINDO PHARMA LTD | +91 (40) 6672 1200 | New Delhi, India | 209 | 58 | Inquiry |
379270-37-8(Tenofovir Alafenamide)Related Search:
Thionyl chloride
D-Alanine Isopropyl Ester HCl
6N-HydroxyMethyl Tenofovir Disoproxil
Tenofovir Related Compound 14
Tenofovir Alafenamide PMPA Impurity
Pimecrolimus
9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
Tenofovir disoproxil
9-Propenyladenine
Tenofovir
DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS*
diisopropyl 2,2'-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(azanediyl))(2S,2'S)-dipropionate compound with methane (1:1)
Tenofovir Related Compound 6
Tenofovir disoproxil fumarate
phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
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Tenofovir Alafenamide fumarate, N-[[S(P)]-[2-(Adenin-9-yl)-1(R)-methylethoxymethyl](phenoxy)phosphoryl]-L-alanine isopropyl ester
(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate
GS-7340/GS7340
GS-7340 Tenofovir alafenamide
tenofovir alafenamide
GS-7340-03
L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)
(2S)-isopropyl 2-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate
L- Alanine,N-[(S)-[[(1R)-2-(6-
N-[[S(P)]-[2-(Adenin-9-yl)-1(R)-methylethoxymethyl](phenoxy)phosphoryl]-L-alanine isopropyl ester
Tenofovir Alafenamide-d6
TENOFOVIR ALAFENAMIDE; GS7340; GS 7340
CS-1724
Tenofovir Alafenamide free base
propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]
methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl
GS7340; GS-7340; GS 7340; TAF; TENOFOVIR ALAFENAMIDE; GENVOYA.
Tenofovir Impurity 51
Tenofovir alafenamide Intermediate 2
Tenofovir Alafenamide Impurity
Tenofovir Alafenamide(TAF)(GS-7340)
Tenofovir alafenamide fumarage
Tenofovir Alafenamide (100mg/mL in Methanol)
isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate
Tenofovir alafenamide semifumarate
Tenofovir Alafenamide USP/EP/BP
N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester
N-[[S(P)]-[2-(Adenin-9-yl)-1(R)-methylethoxymethyl](phenoxy)...
propan-2-yl
(2S)-2-{[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propa
n-2-yl]oxy}methyl)(phenoxy)phosphoryl]amino}pr
opanoate
Tenofovir Alafenamide 25 mg tablets
Tenofovir Alafenamide (GS-7340)
GS-7340
Alafenamide
Tenofovir Alafenamide Base
phenyl hydrogen ((((S)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate
(2R,3S)-2,3-bis(4-chlorophenyl)butane-2,3-diamine
Tenofovir Alafenamide（TAF）(Fumarate)（GS-7340）
Tenofovir and alafenamide
Tenofovir Alafenamide N-2
Tenofovir alafenamide, 10 mM in DMSO
379270-37-8
79270-37-8
392275-56-7
134678-17-7
1292275-56-7
C21H29N6O5P
C25H33N6O9P
Inhibitors
Intermediate
379270-37-8