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Tenofovir alafenamide hemifumarate

Tenofovir alafenamide hemifumarate Structure
CAS No.
1392275-56-7
Chemical Name:
Tenofovir alafenamide hemifumarate
Synonyms
Tenofovir Alafenamide fumarate;GS7340(Tenofovir Alafenamide Fumarate);N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);Anti-HIV;API-Anti-HBV;Tenofovir Alafenamid;GS-7340 (hemifumarate);Alafenamide hemifumarate;Tenofovir levamide amine fumarate
CBNumber:
CB13038481
Molecular Formula:
C25H33N6O9P
Molecular Weight:
592.55
MOL File:
1392275-56-7.mol
Modify Date:
2024/7/2 8:55:00
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Tenofovir alafenamide hemifumarate Properties

storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO:75.0(Max Conc. mg/mL);70.16(Max Conc. mM)
form Solid
color White to off-white
CAS DataBase Reference 1392275-56-7

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Tenofovir alafenamide hemifumarate Chemical Properties,Uses,Production

Definition

ChEBI: Tenofovir alafenamide fumarate is a fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection. It has a role as an antiviral drug, a HIV-1 reverse transcriptase inhibitor and a prodrug. It contains a tenofovir alafenamide(1+).

Clinical Use

Tenofovir alafenamide hemifumarate is useful in the treatment and/or prophylaxis of one or more viral infections in man or animals, including infections caused by DNA viruses. RNA viruses, herpesviruses (e.g., CMV, HSV 1, HSV 2, VZV), retroviruses, hepadnaviruses (e.g., HBV), papillomavirus, hantavirus, adenoviruses and HIV. Like tenofovir disoproxil, tenofovir alafenamide is another prodrug form of tenofovir, and can be used in the treatment and/or prophylaxis of the same conditions.

Drug interactions

Some products that may interact with this drug are: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).

Advantages

One major advantage of the hemifumarate form of tenofovir alafenamide over the monofumarate form is its exceptional capability to purge GS-7339 (i.e., 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine, which is the major diastereomeric impurity in the active pharmaceutical ingredient. Thus, the hemifumarate form of tenofovir alafenamide can be more readily and easily separated from impurities than the monofumarate form. Other major advantages of tenofovir alafenamide hemifumarate over the monofumarate form include improved thermodynamic and chemical stability (including long-term storage stability), superior process reproducibility, superior drug product content uniformity, and a higher melting point.

Tenofovir alafenamide hemifumarate Preparation Products And Raw materials

Raw materials

Preparation Products

Tenofovir alafenamide hemifumarate Suppliers

Global( 315)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Siddhivinayakchemicals +91-912225190111 +91-9819773074 Mumbai, India 42 58 Inquiry
Bulat Pharmaceutical Pvt Ltd +91-8448085659 +91-8448085660 Haryana, India 123 58 Inquiry
Gonane Pharma +91-9819380043 +91-9819380043 NaviMumbai, India 192 58 Inquiry
CDYMAX +91-9019317788 +91-9019317788 Bangalore, India 28 58 Inquiry
Humble Healthcare Limited +91-9720093000 +91-8006400378 Uttar Pradesh, India 141 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Arene Lifesciences Limited +91-9849847907 +91-8455241148 Telangana, India 55 58 Inquiry
Mylan Laboratories Ltd +91-4023550543 +91-4030866666 Telangana, India 150 58 Inquiry
Apicore Pharmaceuticals Pvt Ltd +91-2662267177 +91-2662267166 Gujarat, India 181 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Supplier Advantage
Siddhivinayakchemicals 58
Bulat Pharmaceutical Pvt Ltd 58
Gonane Pharma 58
CDYMAX 58
Humble Healthcare Limited 58
Alembic Pharmaceuticals Limited 58
Arene Lifesciences Limited 58
Mylan Laboratories Ltd 58
Apicore Pharmaceuticals Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58

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1392275-56-7(Tenofovir alafenamide hemifumarate)Related Search:

Tenofovir Alafenamide Tenofovir Diisopropyl Tenofovir FuMarate 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-[6-[[[[9-[(2R)-5-hydroxy-2,11-diMethyl-5-oxido-9-oxo-3,6,8,10-tetraoxa-5-phosphadodec-1-yl]-9H-purin-6-yl]aMino]Methyl]aMino]-9H-purin-9-yl]-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-ox P-[[(1S)-2-(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-phosphonic Acid Monoethyl Ester
Tenofovir Alafenamide Impurity 30 Tenofovir Impurity H (E)-9-(prop-1-en-1-yl)-9H-purin-6-amine Tenofovir Related Compound 6 isopropyl ((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate
TENOFOVIR-D6 Tenofovir Related Compound 1 (((((1-(6-aMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) isopropyl Methyl dicarbonate isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-D-alaninate Tenofovir Disopropyl Ethyl Diester
Mono-POC Tenofovir FuMarate Salt ((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)oxy)methyl dimethylcarbamate Tenofovir disoproxil
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GS-7340 (hemifumarate) Anti-HIV API-Anti-HBV (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1) (R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester Tenofovir alafenamide hemifumarate TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE) Tenofovir levamide amine fumarate (Tenofovir alafenamide : fumarate = 2:1) (S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumarate Tenofovir Alafenamide fumarate [USAN] Alafenamide hemifumarate Tenofovir Alafenamide Hemifumarate(2:1) Tenofovir Alafenamide Fumarate USP/EP/BP Tenofovir Alafenamid Tenofovir Alafenamide Hemifumarate salt[USAN Tenofovir alafenamide hemifumarate (GS-7340) Tenofovir Alafenamide Hemifumarate salt Tenofovir Alafenamide fumarateQ: What is Tenofovir Alafenamide fumarate Q: What is the CAS Number of Tenofovir Alafenamide fumarate L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1) N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1) GS7340(Tenofovir Alafenamide Fumarate) 3H-1,2,4-Triazole-3-thione,4-amino-2,4-dihydro-5-(10-methoxyphenyl)- Tenofovir Alafenamide fumarate Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumarate Tenofovir dipivoxil phenol amine fumarate 2-fluoro-5-[(4' -0x0-3'H-phthalazin-1'-yl)methyllbenzoic acide' Tenofovir Alafenamide Hemifumarate(2:1) CRS Tenofovir Alafenamide Fumarate API GS-7340 (hemifumarate)|||Tenofovir alafenamide fumarate Celiprolol Impurity 8(Celiprolol EP Impurity H) 1392275-56-7 C46H62N12O14P2 2C21H29N6O5PC4H4O4 API 1392275-56-7