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Mycophenolate mofetil

Mycophenolate mofetil Structure
CAS No.
115007-34-6
Chemical Name:
Mycophenolate mofetil
Synonyms
MMF;Mycophenolate Ether;AKOS 92025;Aids059828;Aids-059828;Matimaikaofenzhi;mmf cellcept(tm);Mycophenolate ester;Mycophenolate moftil;Mycophenolate mofetil
CBNumber:
CB2663335
Molecular Formula:
C23H31NO7
Molecular Weight:
433.49
MOL File:
115007-34-6.mol
Modify Date:
2024/7/10 15:15:42
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Mycophenolate mofetil Properties

solubility Practically insoluble in water, freely soluble in acetone, sparingly soluble in anhydrous ethanol.
BCS Class 2
InChI InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+
InChIKey RTGDFNSFWBGLEC-SYZQJQIISA-N
SMILES C12COC(=O)C=1C(O)=C(C/C=C(\C)/CCC(=O)OCCN1CCOCC1)C(OC)=C2C
CAS DataBase Reference 115007-34-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS07,GHS09
Signal word  Danger
Hazard statements  H360-H341-H302-H370-H410
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501-P264-P270-P301+P312-P330-P501-P273-P391-P501

Mycophenolate mofetil Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

Inhibitor of nucleic acid synthesis; immunomodulator.

Indications

Mycophenolate mofetil (CellCept), in conjunction with cyclosporine and corticosteroids, has clinical applications in the prevention of organ rejection in patients receiving allogeneic renal and cardiac transplants. By effectively inhibiting de novo purine synthesis, it can impair the proliferation of both T and B lymphocytes. Following oral administration, mycophenolate mofetil is almost completely absorbed from the GI tract, metabolized in the liver first to the active compound mycophenolic acid, and then further metabolized to an inactive glucuronide.
Early clinical trials indicate that mycophenolate mofetil in conjunction with cyclosporine and corticosteroids is a more effective regimen than azathioprine in preventing the acute rejection of transplanted organs. GI side effects are most common.

Side effects

The main side effects include an increased incidence of herpes zoster, neutropenia, gastrointestinal symptoms, and opportunistic infections. In the transplant literature, 1% to 2% of patients will develop a lymphoproliferative malignancy at the doses recommended for psoriasis. This is a teratogen and should be avoided in women of childbearing age.

Mycophenolate mofetil Preparation Products And Raw materials

Raw materials

Preparation Products

2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate hydrochloride

Mycophenolate mofetil Suppliers

Global( 301)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Shanghai Huici Pharmaceutical Technology Co., LTD +8618917134367 China 133 58 Inquiry
Shanghai Huici Pharmaceutical Technology Co., LTD +8618917134367 China 133 58 Inquiry
Hebei Yanxi Chemical Co., Ltd. +86-17531190177; +8617531190177 China 6011 58 Inquiry
Henan Bao Enluo International TradeCo.，LTD +86-17331933971 +86-17331933971 China 2503 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 11027 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21676 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Xiamen AmoyChem Co., Ltd +86-592-6051114 +8618959220845 China 6387 58 Inquiry
Supplier Advantage
SynZeal Research Pvt Ltd 58
Shanghai Huici Pharmaceutical Technology Co., LTD 58
Shanghai Huici Pharmaceutical Technology Co., LTD 58
Hebei Yanxi Chemical Co., Ltd. 58
Henan Bao Enluo International TradeCo.，LTD 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Xiamen AmoyChem Co., Ltd 58

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Mycophenolate mofetil###115007-34-6 MYCOPHENOLATE MOFETIL,98.0%~102%,ENTERPRISE STANDARD AKOS 92025 4-HEXENOIC ACID,6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-,2-(4-MORPHOLINYL)ETHYL ESTER 2-Morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-hex-4-enoate Mycophenolate mofetil Mycophenolate Mofetil（MMF） Matimaikaofenzhi 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (E)- Aids059828 Aids-059828 mmf cellcept(tm) Mycophenolate Mofetil COS Mycophenolate moftil Mycophenolate mofetil（E） Mycophenolate mofetil CRS Mycophenolate mofetil for peak identification CRS Mycophenolate mofetil (APIs) Mycophenolate mofetil USP/EP/BP Mycophenolate Mofetil Impurit Ⅱ:Mycophenolate Mofet (4E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)4-hexenoic Acid 4-methyl-2-(4-morpholinyl)ethyl Esteril() (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester MMF Mycophenolate Ether Mycophenolate ester RS61443|||Mycophenolate mofetil|||TM-MMF 115007-34-6 15007-34-6 Anti-cancer & immunity API 115007-34-6