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Riociguat

Riociguat Structure
CAS No.
625115-55-1
Chemical Name:
Riociguat
Synonyms
CS-718;Aratac;Riocguat;riocigua;Leosigua;Riociguat;Riociguatr;Bay 63-2521;Amiodaronum;Riociguat (250 mg)
CBNumber:
CB62473752
Molecular Formula:
C20H19FN8O2
Molecular Weight:
422.42
MOL File:
625115-55-1.mol
Modify Date:
2024/6/5 17:10:12
Request For Quotation

Riociguat Properties

Melting point 247-251°C (dec.)
Boiling point 567.2±50.0 °C(Predicted)
Density 1.51
storage temp. Refrigerator
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka 1.51±0.50(Predicted)
form Solid
color Off-White to Orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Riociguat Chemical Properties,Uses,Production

Description

In September 2013, Health Canada approved riociguat (also referred to as BAY 63-2521), for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) after surgical treatment or inoperable CTEPH and for the treatment of adults with pulmonary arterial hypertension (PAH). Riociguat has a dual mode of action and works by (a) sensitizing sGC to the body’s NO by stabilizing NO–sGC binding and (b) an NO-independent, direct stimulation of sGC via a different binding site. This process restores the NO–sGC–cGMP pathway and leads to increased generation of cGMP with subsequent vasodilation.
Headache, dizziness, dyspepsia/gastritis, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation were the most common adverse events ( 3%) observed during riociguat clinical trials. Riociguat comes with a black box warning for embryo-fetal toxicity.

Chemical Properties

Brownish Orange Solid

Uses

Riociguat is used in the treatment for pulmonary hypertension.

Definition

ChEBI: A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension an pulmonary arterial hypertension

Riociguat Preparation Products And Raw materials

Raw materials

Preparation Products

Riociguat Suppliers

Global( 312)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Laxai Life Sciences +91-4023480125 +91-4023480125 Hyderabad, India 21 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Honour Lab Limited +919845977466 Telangana, India 164 58 Inquiry
ALEMBIC PHARMACEUTICALS LTD +91 40 23704923 / 24 / 25 New Delhi, India 108 58 Inquiry
MSN LIFE SCIENCES PRIVATE LTD +91 84523 34200 New Delhi, India 104 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Supplier Advantage
Varanous Labs Pvt Ltd 58
Alembic Pharmaceuticals Limited 58
Laxai Life Sciences 58
Ralington Pharma 58
Honour Lab Limited 58
ALEMBIC PHARMACEUTICALS LTD 58
MSN LIFE SCIENCES PRIVATE LTD 58
CHEMSWORTH 30
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58

Riociguat Spectrum

Riociguat(625115-55-1)1HNMR

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4,6-PyriMidinediaMine, 2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(phenylazo)- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine 1-(2-Fluoro-benzyl)-1H-py...
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Riociguat N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester Bay 63-2521 Carbamic acid, (4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-B)pyridin-3-yl)-5-pyrimidinyl)methyl-, methyl ester Riociguat (BAY 63-2521) Bay63-2521,Riociguat [4,6-DiaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]MethylcarbaMic acid Methyl ester Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate Riociguat N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-, methyl ester fondaparinux sodium intermediateA-8) Riocguat CS-718 Riociguat, BZY 632521 BAY 63-2521; BAY 632521 Riociguat IMpurtiy D methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate riocigua Riociguat USP/EP/BP Riociguatr [4,6-Diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin... Riociguat 13CD3Q: What is Riociguat 13CD3 Q: What is the CAS Number of Riociguat 13CD3 Q: What is the storage condition of Riociguat 13CD3 Q: What are the applications of Riociguat 13CD3 Amiodaronum Aratac Leosigua Riociguat (250 mg) 625115-55-1 615115-55-1 C20H19FN8O2 API