Ambrisentan
- CAS No.
- 177036-94-1
- Chemical Name:
- Ambrisentan
- Synonyms
- CS-135;LU 208075;BSF 208075;AMBRISENTAN;Anrisentan API;((S)-Ambrisentan);(R,S)-Ambrisentan;Ambrisentan, >=98%;Ambrisentan Tablets;(R,S)-AMbrisentan-d5
- CBNumber:
- CB71011125
- Molecular Formula:
- C22H22N2O4
- Molecular Weight:
- 378.42
- MOL File:
- 177036-94-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/8 15:48:27
| Melting point | >150°C (dec.) |
|---|---|
| Boiling point | 551.1±60.0 °C(Predicted) |
| Density | 1.228±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 0.97±0.10(Predicted) |
| color | White to Off-White |
| Merck | 14,384 |
| InChI | InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26) |
| InChIKey | OUJTZYPIHDYQMC-UHFFFAOYSA-N |
| SMILES | C(OC1N=C(C)C=C(C)N=1)(C(O)=O)C(OC)(C1=CC=CC=C1)C1=CC=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360FD | |||||||||
| Precautionary statements | P201-P308+P313 | |||||||||
| Risk Statements | 62/63 | |||||||||
| Safety Statements | 53-36/37/39-45 | |||||||||
| RTECS | UA2459660 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Ambrisentan price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2104 | Ambrisentan ≥98% (HPLC) | 177036-94-1 | 10MG | ₹13730.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2104 | Ambrisentan ≥98% (HPLC) | 177036-94-1 | 50MG | ₹55222.5 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2966 | Ambrisentan | 177036-94-1 | 20MG | ₹3500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A2966 | Ambrisentan | 177036-94-1 | 100MG | ₹7900 | 2022-05-26 | Buy |
Ambrisentan Chemical Properties,Uses,Production
Description
Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.
Chemical Properties
White to Off White Solid
Uses
Nonpeptide endothelin ETA receptor antagonist. Antihypertensive
General Description
Ambrisentan, (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid(Letairis), is a potent ETA selective endothelin antagonist that,is indicated, in the treatment of pulmonary arterial hypertension(PAH). PAH is a rare disease that if left untreated has ahigh mortality rate. In June of 2007, the FDA granted approvalof ambrisentan for once-daily treatment of PAH.Studies have shown that it improves a 6-minute walk by about30 to 60 m for patients receiving placebo.
Ambrisentan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Horizon | +91-7517039862 +91-7517039862 | Maharashtra, India | 36 | 58 | Inquiry |
| Cipla Ltd | +912224826000 | Maharashtra, India | 133 | 58 | Inquiry |
| Megafine Pharma | +91 9867686666, +91 9665458868 | Maharashtra, India | 29 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Mylan Laboratories Ltd | +91-4023550543 +91-4030866666 | Telangana, India | 150 | 58 | Inquiry |
| KPS Chemicals And Pharmaceuticals | +91-9870076629 +91-8469484608 | Gujarat, India | 33 | 58 | Inquiry |
| Enaltec Labs Pvt Ltd | +91-9167119247 +91-9167119247 | Maharashtra, India | 49 | 58 | Inquiry |
| Sun Pharmaceutical Industries Ltd. | 91-22-43244324 | Maharashtra, India | 99 | 58 | Inquiry |
| Indexim International | 08048971004 | Gujarat, India | 112 | 58 | Inquiry |
| Well Wisher Pharma | 08048979521 | Delhi, India | 2 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Horizon | 58 |
| Cipla Ltd | 58 |
| Megafine Pharma | 58 |
| Ralington Pharma | 58 |
| Mylan Laboratories Ltd | 58 |
| KPS Chemicals And Pharmaceuticals | 58 |
| Enaltec Labs Pvt Ltd | 58 |
| Sun Pharmaceutical Industries Ltd. | 58 |
| Indexim International | 58 |
| Well Wisher Pharma | 58 |
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