Ambrisentan
Ambrisentan
- CAS:
- 177036-94-1
- MF:
- C22H22N2O4
- MW:
- 378.42
Suppliers by country/region
Company Type
Properties
- Melting point:
- >150°C (dec.)
- Boiling point:
- 551.1±60.0 °C(Predicted)
- Density
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 0.97±0.10(Predicted)
- color
- White to Off-White
- Merck
- 14,384
- InChI
- InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
- InChIKey
- OUJTZYPIHDYQMC-UHFFFAOYSA-N
- SMILES
- C(OC1N=C(C)C=C(C)N=1)(C(O)=O)C(OC)(C1=CC=CC=C1)C1=CC=CC=C1
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H360FD
- Precautionary statements
- P201-P308+P313
- Risk Statements
- 62/63
- Safety Statements
- 53-36/37/39-45
- RTECS
- UA2459660
- HS Code
- 29335990
Use
Ambrisentan, (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid(Letairis), is a potent ETA selective endothelin antagonist that,is indicated, in the treatment of pulmonary arterial hypertension(PAH). PAH is a rare disease that if left untreated has ahigh mortality rate. In June of 2007, the FDA granted approvalof ambrisentan for once-daily treatment of PAH.Studies have shown that it improves a 6-minute walk by about30 to 60 m for patients receiving placebo.
14 India supplier list of "Ambrisentan"
- Product Name:Ambrisentan
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Trader
- Country/Region: Maharashtra,INDIA
- Product Name:Ambrisentan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Ambrisentan
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Ambrisentan
- Products Intro:Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Ambrisentan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Ambrisentan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:Ambrisentan
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:Ambrisentan
- Products Intro:Brand:sigma aldrich | Product Number:SML2104 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Ambrisentan 98%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.133444
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:Ambrisentan
- Company Type: Reagent
- Country/Region: Hyderabad,INDIA